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Description
Phospho-SMAD2/3 (Thr8) Recombinant Rabbit mAb (S-3372-136)Product Specification Host Rabbit Antigen Phospho SMAD2 3 (Thr8) Synonyms SMAD family member 2; hSMAD2; JV18 1; Mad related protein 2 (hMAD 2); Mothers against decapentaplegic homolog 2 (MAD homolog 2; Mothers against DPP homolog 2); MADH2; MADR2; SMAD family member 3; hSMAD3; JV15 2; Mothers against decapentaplegic homolog 3 (MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD 3); MADH3 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus
Product Specification
| Host | Rabbit |
| Antigen | Phospho-SMAD2/3 (Thr8) |
| Synonyms | SMAD family member 2; hSMAD2; JV18-1; Mad-related protein 2 (hMAD-2); Mothers against decapentaplegic homolog 2 (MAD homolog 2; Mothers against DPP homolog 2); MADH2; MADR2; SMAD family member 3; hSMAD3; JV15-2; Mothers against decapentaplegic homolog 3 (MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3); MADH3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q15796、P84022 |
| Clone Number | S-3372-136 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | 293T, RAW264.7, PC-12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
Phospho-SMAD2/3 (Thr8) refers to the phosphorylation of SMAD2 and SMAD3 proteins at threonine 8, a site distinct from their canonical C-terminal SXS motif phosphorylation by TGF-β receptors. This alternative phosphorylation is typically mediated by MAP kinases (ERK, JNK, p38) or CDKs in response to various stimuli including growth factors, stress, and cell cycle signals. It modulates SMAD transcriptional activity, stability, and subcellular localization, serving as a regulatory crossroad between TGF-β signaling and other pathways. Aberrant Thr8 phosphorylation has been implicated in cancer progression and fibrotic diseases, influencing cell proliferation, migration, and epithelial-mesenchymal transition.
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