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Description
GPR40 Recombinant Rabbit mAb (S-3817-50)Product Specification Host Rabbit Antigen GPR40 Synonyms Free fatty acid receptor 1; FFAR1 Immunogen Synthetic Peptide Location Cell membrane Accession O14842 Clone Number S 3817 50 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HepG2, MCF7, MIN6, mouse pancreas, rat pancreas, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | GPR40 |
| Synonyms | Free fatty acid receptor 1; FFAR1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | O14842 |
| Clone Number | S-3817-50 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HepG2, MCF7, MIN6, mouse pancreas, rat pancreas, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
Background
GPR40, also known as Free Fatty Acid Receptor 1 (FFAR1), is a G protein-coupled receptor primarily expressed in pancreatic beta cells and enteroendocrine cells that plays a pivotal role in metabolic regulation by sensing circulating medium- and long-chain free fatty acids. Upon activation by these dietary lipids, GPR40 triggers an intracellular signaling cascade involving Gq/11 proteins, which leads to increased phospholipase C activity, elevated intracellular calcium levels, and the subsequent potentiation of glucose-stimulated insulin secretion (GSIS) without directly inducing insulin release in the absence of glucose. This unique mechanism makes GPR40 a highly attractive therapeutic target for type 2 diabetes, as its agonists can enhance insulin output in a glucose-dependent manner, thereby minimizing the risk of hypoglycemia, while also stimulating the release of incretin hormones like GLP-1 from intestinal L-cells to further improve glycemic control and potentially preserve beta-cell function.
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4.2 ★★★★★
Based on 26 reviews
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Product Reviews
★★★★★ 5
Simplicity
Color: Black/Orange
This watch was received exactly as advertised. First off the watch is economical compared to other watches that advertise the same details. I will say that I have gone through numerous Luminox watches only to be disappointed. This watch fits the bill. It does have solar cells which mean it needs to be exposed to light to keep running, not a problem. Three minutes under my surefire light I am golden. The bezel doesn't rotate actually no big deal for me. I have always required that the bezel moves not anymore after having a bezel that rotates I use it next to never. Here's why, the more I rotate the bezel the more the numbers wear off. The strap on the watch with the catches for the strap are perfect. They actually hold the watch strap in place in lieu of like other big name brands that just flop and slide. As far as everyday use goes this watch is my go to. To be honest I have purchased three. This is the only watch I will wear moving forward, yeah the glass my scratch but even the big names like the Luminox I spoke of earlier scratches too.
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Reviewed in the United States on April 4, 2026
★★★★★ 5
Real men wear pink!
Bought for hubby and he's happy! Not a bubblegum pink but a more subtle shade. Pale rose, kind of. Flattering fit, too.
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Reviewed in the United States on December 16, 2024
★★★★★ 4
True to size, and looks exactly as pictured
What you see is what you get. The picture is accurate, and the sizing is right. I ordered a size 3XL and it is accurately a size 3XL.
The shirt material is a nice thickness without being see thru but also not being too thick. The pattern and color makes it forgiving on sweat when you do sweat. It is the wicking style of clothing.
The collar is denser/thicker/reinforced more than many polo styled shirts so the color pops up more than thinner shirts. The stitching and material are quality too.
The interior tag has a spare button and it says designed in Italy. The amazon page says it is made in China. I am actually kind of surprised at the price, and the fact that it is made in China. I held my breath a little and assumed it would be much lower quality. I was happy to find out that this is a nice, solid shirt.
For gift giving purposes, I am giving this one star lower. For personal purposes, it is definitely 5 star.
The reason I give it 4 stars is because the shirt comes in a sort of crappy clear box which is easily smashed in transit and quite frankly looks really cheap when you gift it, in my opinion. It says new on the sticker, made in china, but I would absolutely take it out of the box if you gift it. Also, there isn't a price tag or any kind of removable tag on the shirt at all. So, if I take it out of the box, and wrap it separately it doesn't have the ''hey, this is a new item tag.''
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Reviewed in the United States on November 3, 2024
★★★★★ 5
Comfortable and Stylish Polo Shirt for Any Occasion
I recently tried out the J.VER Men's Polo Shirt, and I’m really happy with the fit, feel, and overall look of the shirt. The fabric is a great combination of polyester and spandex, making it stretch just enough to feel comfortable while still offering a flattering fit. The material is lightweight yet durable, which makes it perfect for the warmer months. It’s breathable and quick-drying, so it keeps me cool even when I’m outdoors or active. Whether I’m out on the golf course or just relaxing, this polo feels great to wear.
One of the things I like most about this shirt is how versatile it is. The classic design makes it suitable for both casual and more formal settings. I’ve worn it to a couple of casual business meetings, and it’s comfortable enough for a day of golf or a weekend outing. The collar is solid, with a nice touch of style thanks to the subtle pattern, and it holds its shape well after multiple washes. It’s not too stiff, so it feels natural around the neck, but it still maintains a neat, structured look.
Another thing worth mentioning is the fit. The shirt fits true to size, and it has just the right amount of stretch. It’s not too tight or too loose, and the length is perfect for wearing tucked in or left out. I’ve tried other polos in the past that either feel too boxy or too clingy, but this one strikes a nice balance. It’s flattering without feeling restrictive. The side split design also adds to its comfort and flexibility, especially when I’m moving around or swinging a club.
All in all, I’m very happy with this polo shirt. It’s stylish, comfortable, and functional. I appreciate the thoughtful design and quality of the material, which has held up well so far. This is a great addition to my wardrobe, and I can see myself wearing it for a variety of occasions. Whether you’re looking for a shirt for outdoor activities or something that works for both business and casual wear, this polo is a solid choice.
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Reviewed in the United States on November 17, 2024
★★★★★ 4
Fits nicely
I always prefer a dry fit shirt, because of the way it fits me, and falls on my frame. I find this shirt nicely tailored, and flattering for my body type. Just to give you a little perspective, I am 5 foot 11 and 195 lbs, with a muscular build. I chose the size large, and I find it fits me very well. I don't like shirts to look like they're painted on, and I want a little bit of looseness for comfort. I also like a shirt that is made from comfortable good breathing material, and this one checks all of those boxes. The large is not loose on me by any means, but it is a nice size for my frame. It's neither too loose, nor too tight, and straddles that Goldilocks sizing zone. The blue has a very nice look to it, with a little bit of black thread incorporated as well. So, it has this subtle two tone look to it throughout. The collar inlay has a different design pattern, which is also very nice. I could certainly see this shirt being a great golf shirt, and one that is flexible to accommodate my swing. All in all, I'm very happy with it, find it stylish, and would comfortably recommend it. The only thing I would mention, is that it did have a scent of what to me smelled like new car smell. It smells like that new fabric, when you sit in a car in the showroom. I suspect that'll go away with a wash or two, so it's not a big deal, neither is it off putting.
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Reviewed in the United States on November 13, 2024