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Description
Biotin Rat Anti-Mouse CD150 Antibody (S-R738)Product Specification Host Rat Antigen CD150 Synonyms Signaling lymphocytic activation molecule; SLAM family member 1; Slam; Slamf1 Location Cell membrane Accession Q9QUM4 Clone Number S R738 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Rat |
| Antigen | CD150 |
| Synonyms | Signaling lymphocytic activation molecule; SLAM family member 1; Slam; Slamf1 |
| Location | Cell membrane |
| Accession | Q9QUM4 |
| Clone Number | S-R738 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD150, also known as SLAM (Signaling Lymphocytic Activation Molecule), is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily and encoded by the SLAMF1 gene. It is primarily expressed on various hematopoietic cells, including T cells, B cells, natural killer cells, dendritic cells, monocytes, and macrophages. CD150 serves multiple functions: it acts as a co-stimulatory molecule in immune cell activation, a receptor for morbilliviruses such as measles virus, and a bacterial sensor on macrophages. The protein has several isoforms, including a transmembrane form (mCD150), a secreted form (sCD150), and a novel transmembrane form (nCD150) with an alternative cytoplasmic tail. CD150 mediates homophilic interactions and can transmit either activating or inhibitory signals depending on the cell type and context.
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