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Description
Human GDF-15(Culture Medium) OneStep ELISA KitProduct Specification Antigen GDF 15 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 5. 9% Inter assay: 9. 4% Sample type Cell culture supernatant Assay type Sandwich (quantitative) Sensitivity 0. 997 pg mL Range 3. 906 pg mL 250 pg mL Recovery Cell culture supernatant: 94% Assay time 60
Product Specification
| Antigen | GDF-15 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 5.9%； Inter-assay: 9.4% |
| Sample type | Cell culture supernatant |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.997 pg/mL |
| Range | 3.906 pg/mL – 250 pg/mL |
| Recovery | Cell culture supernatant: 94% |
| Assay time | 60 minutes |
| Species reactivity | Hu |
Background
Human Growth Differentiation Factor 15 (GDF-15), also known as MIC-1 or PDF, is a stress-responsive cytokine belonging to the TGF-β superfamily. Primarily secreted by macrophages, epithelial cells, and placental tissues under pathological conditions, this 25-kDa dimeric protein signals through the glial cell-derived neurotrophic factor (GDNF) family receptor α-like (GFRAL)-RET complex in the brainstem. It regulates systemic energy homeostasis by suppressing appetite and modulating insulin sensitivity, while also functioning as a biomarker for cellular stress, cardiovascular disease, and cancer progression. Elevated GDF-15 levels correlate with cachexia, heart failure, and tumor metastasis, making it a therapeutic target for metabolic disorders and a diagnostic indicator for tissue damage. Its expression increases >100-fold during starvation, inflammation, and oxidative stress.
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