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Description
APC Rat Anti-Mouse CD335 Antibody (S-R613)Product Specification Host Rat Antigen CD335 Synonyms Natural cytotoxicity triggering receptor 1; Activating receptor 1 (mAR 1); Lymphocyte antigen 94; Natural killer cell p46 related protein (NK p46; NKp46; mNKp46); Ly94; Ncr1 Location Cell membrane Accession Q8C567 Clone Number S R613 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2mg ml
Product Specification
| Host | Rat |
| Antigen | CD335 |
| Synonyms | Natural cytotoxicity triggering receptor 1; Activating receptor 1 (mAR-1); Lymphocyte antigen 94; Natural killer cell p46-related protein (NK-p46; NKp46; mNKp46); Ly94; Ncr1 |
| Location | Cell membrane |
| Accession | Q8C567 |
| Clone Number | S-R613 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 0.2% BSA, 0.1% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
CD335, also known as NKp46 or Natural Cytotoxicity Triggering Receptor 1 (NCR1), is a 46 kDa type I transmembrane glycoprotein that belongs to the natural cytotoxicity receptor family. It is primarily expressed on natural killer (NK) cells and plays a crucial role in their activation and cytotoxicity. CD335 can recognize and bind to viral hemagglutinins and heparan sulfate proteoglycans on target cells, triggering NK cell-mediated cytotoxic responses. This receptor is involved in non-MHC-restricted natural cytotoxicity and is essential for the immune system's ability to detect and eliminate infected or transformed cells.
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