SKU: 86620593282

UniOne® TR-FRET Human BRD4/CRBN PROTAC Binding Kit

$981.00 $1090.00
Save 10%
No.2 Bestseller on watersyst.com >

Pay in installments of $272.50 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 21 - Jul 26

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

UniOne® TR-FRET Human BRD4/CRBN PROTAC Binding KitProduct Specification Host Human Stability & Storage 80 Background This kit utilizes Homogeneous Time Resolved Fluorescence(TR FRET) technology to measure the Molecular Glue BET Degrader 1 and testcompound mediated interaction between the DDB1 CRBN complex and BRD4. BRD4contains bromodomain 1 and 2. This method enables a simple and rapidhigh throughput format for detecting small molecules capable of mediating theinteraction between the DDB1 CRBN

Product Specification


Host Human
Stability & Storage

-80℃

Background

This kit utilizes Homogeneous Time-Resolved Fluorescence(TR-FRET) technology to measure the Molecular Glue BET Degrader-1 and testcompound-mediated interaction between the DDB1/CRBN complex and BRD4. BRD4contains bromodomain 1 and 2. This method enables a simple and rapidhigh-throughput format for detecting small molecules capable of mediating theinteraction between the DDB1/CRBN complex and BRD4.

As shown, the interaction between DDB1/CRBN and BRD4 isdetected using a Eu-labeled Anti-Tag1 Antibody (TR-FRET donor) and anAcceptor-labeled Anti-Tag2 Antibody (TR-FRET acceptor). As the Molecular GlueBET Degrader-1 mediates the interaction between DDB1/CRBN and BRD4, the donorand acceptor antibodies are brought into proximity. Excitation of the donor antibodytriggers Fluorescence Resonance Energy Transfer (FRET) to the acceptorantibody, resulting in a specific emission signal at 665nm. This specificsignal is proportional to the degree of interaction mediated by BET Degrader-1between DDB1/CRBN and BRD4. This homogeneous assay is simple to perform andrequires no washing steps.



Components

Component

Concentration

500 TESTS

2500 TESTS

10000 TESTS

Storage Temp.

Tag1-DDB1/CRBN protein

25×

80μL

400μL

1600μL

-80°C

Tag2-BRD4 protein

100×

20μL

100μL

400μL

-80°C

BET Degrader-1 (100μM)

10μM

10μL

50μL

200μL

-80°C

Anti-Tag1 Eu dye antibody

50×

50μL

250μL

1000μL

-80°C

Anti-Tag2 Ac antibody

12.5×

200μL

1000μL

4000μL

-80°C

Detection buffer

10×

2mL

10mL

40mL

-80°C

*Repeated freeze-thaw cycles should be avoided. Aliquot upon first thaw and store according to the specified conditions. Valid for one year.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 86620593282

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.3 ★★★★★
Based on 22 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
E
Elis
Whiting, US
★★★★★ 5
Camouflages well with the skin and sticks long enough
I was excited to try these Halo Dot patches because I was having some breakouts before a wedding I had to attend. I put these on three nights before the wedding only at nights and left them on until the morning. I washed my face the 1st night, yet the second night I did not and it still attached (mind that I have a very oily face by the end of the day). With every application I saw good results as the breakouts were being reduced with each use. It is easy to put on and to carry out if you need to travel because it comes in two separate little envelope like package that you can put in a backpack/purse. These are thin and are almost not visible.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 14, 2026
B
Beachcomber
Carnegie, US
★★★★★ 4
Easy to Use and Surprisingly Effective
Even though I am well past the age when I thought breakouts would stop happening, I still get the occasional pimple. As luck would have it, I felt one starting to pop up on my cheek the day after these Halo Dot Pimple Patches arrived. Before bed, after washing and thoroughly drying my face, I applied one of the patches. It peeled easily from the backing sheet, and when I realized I had not placed it quite right, I was pleasantly surprised that I could lift and reposition it without any trouble. What really impressed me was how well it blended into my skin. I was only wearing it overnight, but honestly, I do not think anyone would have noticed it unless they were looking very closely. In fact, I forgot I even had it on until I looked in the mirror the next morning. The patch peeled off easily and had clearly pulled some of the buildup from the blemish overnight. There was no redness or irritation afterward, and the spot looked dramatically improved by morning. The only downside for me is the price, especially since the package contains just 33 patches. That said, if they continue to work this well, I would definitely consider purchasing them again.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 10, 2026
S
Summerr
Pawtucket, US
★★★★★ 5
Love these already! Came in handy just when I need it!
These acne patches came in really handy when I had a random breakout near my lip, especially since that’s an area where I tend to wear a lot of makeup. They helped gently draw out impurities without being harsh on my skin. I also like that they blend in well on the skin. They’re not tinted, but they still work nicely across different skin tones like advertised, which makes them less noticeable while wearing them. You get a good amount in the package as well—33 patches total, with 18 patches on each sheet. Overall, they’re convenient to have on hand for unexpected breakouts, and I would definitely recommend them.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 18, 2026
V
Verified Purchase
Verucat
Birmingham, US
★★★★★ 5
Yes!
Size: Medium
Durable. Squeak doesn't last forever with my aggressive chewers but crinkle does. Best balls.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 28, 2025
J
Verified Purchase
JJ Fording
San Leandro, US
★★★★★ 5
Balls
Size: Medium
My dog loves chasing these balls. He seems to love the squeak! They fit the chuck it stick perfectly, and are great replacements for the originals that came with the stick.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 7, 2026

recommand products

Tracy v01s - Heart Pendant Bangle Bracelet
39.95
Becky v01s - Bangle Bracelet
39.95
Victoria v01s - Heart Pendant Bangle Bracelet
39.95
Angela v01s - Bangle Bracelet
39.95
Nellie v01s - Heart Pendant Bangle Bracelet
39.95