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Description
Biotin Rat Anti-Mouse CD62L Antibody (S-R475)Product Specification Host Rat Antigen CD62L Synonyms L selectin; CD62 antigen like family member L; Leukocyte adhesion molecule 1 (LAM 1); Leukocyte endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; Lymphocyte antigen 22 (Ly 22); Lymphocyte surface MEL 14 antigen; Lnhr; Ly 22; Ly22; Sell Location Cell membrane Accession P18337 Clone Number S R475 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive
Product Specification
| Host | Rat |
| Antigen | CD62L |
| Synonyms | L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1 (LAM-1); Leukocyte-endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; Lymphocyte antigen 22 (Ly-22); Lymphocyte surface MEL-14 antigen; Lnhr; Ly-22; Ly22; Sell |
| Location | Cell membrane |
| Accession | P18337 |
| Clone Number | S-R475 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD62L (L-Selectin) is a type-I transmembrane glycoprotein and a member of the selectin family of adhesion molecules, constitutively expressed on most circulating leukocytes, including lymphocytes (except a substantial population of memory T cells), monocytes, and polymorphonuclear cells. It plays a crucial role in the immune response by mediating the rolling adhesion of leukocytes to endothelial cells, which is essential for lymphocyte homing to secondary lymphoid organs and for the migration of monocytes and neutrophils into inflamed tissues. Structurally, L-Selectin consists of an N-terminal C-type lectin domain, an epidermal growth factor (EGF)-like domain, two short consensus repeat (SCR) sequences, a transmembrane region, and a short cytoplasmic tail. The N-terminal lectin domain interacts with specific carbohydrate ligands such as sialyl Lewis X (sLex) to facilitate adhesion. Additionally, L-Selectin is involved in embryonic implantation by aiding the attachment of the blastocyst to the endometrial endothelium.
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