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Description
Biotinylated CLEC12A/MICL/CLL-1 Avi&His Tag Protein, HumanProduct Specification Species Human Synonyms CLL1, DCAL2 Accession Q5QGZ9 2 Amino Acid Sequence His65 Ala265, with N terminal His and Avitag Expression System HEK293 Molecular Weight 35 45kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability & Storage 12 months
Product Specification
| Species | Human |
| Synonyms | CLL1, DCAL2 |
| Accession | Q5QGZ9-2 |
| Amino Acid Sequence | His65-Ala265, with N-terminal His and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Vitry, J.; Paré, G.; Murru,A.; Charest-Morin, X.; Maaroufi, H.;McLeish, K.R.; Naccache, P.H.;Fernandes, M.J. Regulation of the Expression, Oligomerisation and Signaling of the Inhibitory Receptor CLEC12A by Cysteine Residues in the Stalk Region. Int. J. Mol. Sci. 2021,22, 10207. |
Background
Clec12a (also called myeloid inhibitory C-type lectin-like receptor, MICL) was originally described as an ITIM-containing inhibitory CLR expressed by human granulocytes and monocytes. It was suggested that Clec12a recognizes some endogenous ligands as soluble Clec12a could bind to single-cell suspensions isolated from various murine tissues. CLEC12A is a myeloid lineage antigen that is highly expressed by AML cells and LSCs, but not expressed by normal hematopoietic stem cells (HSCs), thus minimizing off-target toxicity.
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