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Description
TROP1/EPCAM Recombinant Rabbit mAb (S-1379-5)Product Specification Host Rabbit Antigen TROP1 EPCAM Synonyms Epithelial cell adhesion molecule; Ep CAM; Epithelial glycoprotein 314 (EGP314; mEGP314); Protein 289A; Tumor associated calcium signal transducer 1; CD326; Tacstd1; Epcam Immunogen Recombinant Protein Location Cell membrane Accession Q99JW5 Clone Number S 1379 5 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Ms, Rt Positive Sample mouse colon, rat colon
Product Specification
| Host | Rabbit |
| Antigen | TROP1/EPCAM |
| Synonyms | Epithelial cell adhesion molecule; Ep-CAM; Epithelial glycoprotein 314 (EGP314; mEGP314); Protein 289A; Tumor-associated calcium signal transducer 1; CD326; Tacstd1; Epcam |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q99JW5 |
| Clone Number | S-1379-5 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Ms, Rt |
| Positive Sample | mouse colon, rat colon |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:1000-1:2000 | Ms, Rt |
| IF | 1:500 | Ms, Rt |
Background
TROP1, also known as EpCAM (Epithelial Cellular Adhesion Molecule) or CD326, is a 40 kDa type I transmembrane glycoprotein that plays crucial roles in various cellular processes. It consists of an extracellular domain with two epidermal-growth-factor-like (EGF-like) repeats, a transmembrane segment, and a cytoplasmic domain. EpCAM is highly conserved between species, with 82% amino acid sequence identity between humans and mice. It is expressed in various tissues during embryonic development and in adult simple, pseudo-stratified, and transitional epithelia, but not in normal squamous epithelia or mesenchymal tissues. EpCAM is upregulated in proliferating epithelial tissues, during liver regeneration, and in many carcinomas, making it a potential target for cancer therapy. Functionally, EpCAM acts as a homophilic Ca²⁺-independent adhesion molecule, forming dimers and tetramers that interact with the actin cytoskeleton and regulate cell adhesion, proliferation, and epithelial-to-mesenchymal transition.
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