SKU: 90749489529

Human TPX2, His tag

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Description

Human TPX2, His tagProduct Specification Species Human Synonyms Differentially expressed in cancerous and non cancerous lung cells 2 (DIL 2), Hepatocellular carcinoma associated antigen 519, Hepatocellular carcinoma associated antigen 90, Protein fls353, Restricted expression proliferation associated protein 100 (p100), C20orf1, C20orf2, DIL2, HCA519 Accession Q9ULW0 Amino Acid Sequence Protein sequence (Q9ULW0, Gln213 Asp349, with C 10*His)

Product Specification


Species Human
Synonyms Differentially expressed in cancerous and non-cancerous lung cells 2 (DIL-2), Hepatocellular carcinoma-associated antigen 519, Hepatocellular carcinoma-associated antigen 90, Protein fls353, Restricted expression proliferation-associated protein 100 (p100), C20orf1, C20orf2, DIL2, HCA519
Accession Q9ULW0
Amino Acid Sequence

Protein sequence (Q9ULW0, Gln213-Asp349, with C-10*His) QELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDGGGGSHHHHHHHHHH

Expression System E.coli
Molecular Weight Predicted MW: 17.9 kDa Observed MW: 18 kDa
Purity >90% by SDS-PAGE
Tag with C-10*His
Physical Appearance Lyophilized Powder
Storage Buffer Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. It is one of the many spindle assembly factors that play a key role in inducing microtubule assembly and growth during M phase. Because of its integral role in microtubule assembly and therefore mitosis, TPX2 is found to be overexpressed in different types of human cancers including hepatocellular carcinoma (HCC), medullary thyroid cancer, bladder carcinoma, and estrogen receptor-positive metastatic breast cancer and contributes to tumor growth and metastasis. As a result, TPX2 has recently been a topic of interest for learning more about the relationship between mitotic errors and tumorigenesis, along with novel cancer therapies.

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SKU: 90749489529

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4.5 ★★★★★
Based on 26 reviews
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Product Reviews
G
Verified Purchase
Gwen D.
Carnegie, US
★★★★★ 5
It's one of the only toys that we originally got for our pup that has lasted
Color: Blue goose - pineapple plush
We got a lab mix (we think with a Great Dane) on Labor Day weekend 2025. She has destroyed 100% of the toys we got her that weekend, with the exception of this duck. Yes, it is missing it's feet at this point (they got chewed off and torn sometime around Halloween), but the duck itself is still intact. She chews on the duck every day, it's one of her favorite toys, and it's seen some things. We've washed it a few times in the laundry machine, and it looks nice a clean every time we pull it out and let it dry. She's gnawed on it through losing puppy teeth and getting adult teeth, and she's is currently chewing away on her duck on her bed in the living room. I understand others have reported really mixed reviews, but I'm so glad we got this duck and it's one of the only toys we've bought that I feel like was worth the price because it didn't get destroyed immediately. We plan on buying another one for Christmas.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 18, 2025
M
Verified Purchase
mike
Port Orchard, US
★★★★★ 5
It's not indestructible
Color: Blue goose - pineapple plush
Great toy , but not indestructible didn't take long at all for my dog to see the wings off
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 25, 2026
J
Verified Purchase
Justin
Whiting, US
★★★★★ 3
My Dog Hates It, Yours Might Like It
Color: Blue goose - pineapple plush
Material is nice, squeaker is not that great. My dog hates this toy and refuses to interact with it I've tried multiple times to get him to play with it and he'll immediately stop playing if I touch this toy and try to get him to play with it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 29, 2026
C
Verified Purchase
Cellina Danvers
Belleville, US
★★★★★ 2
Not worth the purchase
Color: Blue goose - pineapple plush
Not for aggressive chewers, my GWP destroyed this in 30 mins. The fins are completely gone and he’s already disinterested. There are better options out there.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 27, 2026
K
Verified Purchase
Kindle CustomerJoanne
Phoenix, US
★★★★★ 4
He loved the toy
Color: Blue goose - pineapple plush, Color: Blue goose - pineapple plush
My dog loved this toy, however it is not indestructible, he had it in 2 pieces within a day, but I do need to say he is a big boy and we haven’t found a toy yet that he can’t destroy
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 10, 2026

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