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Description
Mouse Anti-Human CD196 Antibody (S-R645)Product Specification Host Mouse Antigen CD196 Synonyms C C chemokine receptor type 6; C C CKR 6; CC CKR 6; CCR 6; Chemokine receptor like 3 (CKR L3); DRY6; G protein coupled receptor 29; GPR CY4 (GPRCY4); LARC receptor; CCR6; CKRL3; CMKBR6; GPR29; STRL22 Location Cell membrane Accession P51684 Clone Number S R645 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 2 mg
Product Specification
| Host | Mouse |
| Antigen | CD196 |
| Synonyms | C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; Chemokine receptor-like 3 (CKR-L3); DRY6; G-protein coupled receptor 29; GPR-CY4 (GPRCY4); LARC receptor; CCR6; CKRL3; CMKBR6; GPR29; STRL22 |
| Location | Cell membrane |
| Accession | P51684 |
| Clone Number | S-R645 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD196, also known as CCR6, is a seven-transmembrane G protein-coupled receptor belonging to the beta-chemokine receptor family. It is expressed on B cells, subsets of T cells, dendritic cells, natural killer cells, and Langerhans cells. CD196 binds to its ligand CCL20 (MIP-3α) and plays a key role in regulating the migration and recruitment of immune cells, particularly in inflammatory and immune responses. Additionally, CD196 is involved in the differentiation of Th17 cells and the development of regulatory T cells (CD4+FoxP3+). In pathological contexts, CD196 is associated with various diseases, including autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease, as well as certain cancers.
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Exchange/Return Notes
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