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Description
DPP4/CD26 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms ADABP, ADCP2, DPPIV, TP103 Accession P27487 Amino Acid Sequence Asn29 Pro766, with N hIgG1 Fc Expression System HEK293 Molecular Weight 105 120 kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability &
Product Specification
| Species | Human |
| Synonyms | ADABP, ADCP2, DPPIV, TP103 |
| Accession | P27487 |
| Amino Acid Sequence | Asn29-Pro766, with N-hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 105-120 kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Klemann C. et al. (2016) Cut to the chase: a review of CD26/dipeptidyl peptidase-4’s (DPP4) entanglement in the immune system. Clin Exp Immunol. 185(1): 1-21. 2、Mortier A. et al. (2016) CD26/dipeptidylpeptidase IV—chemokine interactions: double-edged regulation of inflammation and tumor biologyJ. Leukoc Biol. 99(6): 955-969. 3、Rohrborn D. et al. (2014) Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells. FEBS Lett. 588(21): 3870-3877. 4、Enz N. et al. (2019) CD26/DPP4 - a potential biomarker and target for cancer therapy. Pharmacol Therapeiut. 198: 135-159. |
Background
Dipeptidyl peptidase 4 (DPPIV, also known as CD26) is an approximately 110 kDa serine exopeptidase that releases Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of oligo- and polypeptides. Mature human DPPIV consists of a 6 amino acid (aa) cytoplasmic tail, a 22 aa transmembrane segment, and a 738 aa extracellular domain (ECD) that contains the catalytic active site. DPPIV is expressed as a noncovalent homodimer on the surface of epithelial cells, endothelial cells, and activated lymphocytes, and it can be released by MMP mediated shedding. It regulates immune and endocrine function through the cleavage of multiple chemokines, growth factors, and peptide hormones. CD26/dipeptidyl peptidase (DPP) 4 is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metastases express CD26/DPP4 to a variable extent. By cleaving dipeptides from peptides with a proline or alanine in the penultimate position at the N-terminus, it regulates the activity of incretin hormones, chemokines and many other peptides. Due to these effects and interactions with other molecules, a tumor promoting or suppressing role can be attributed to CD26/DPP4. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.
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4.3 ★★★★★
Based on 23 reviews
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Product Reviews
★★★★★ 5
Works well. You need to drill a 3/8” hole
Appears to be well made, alignment bar slides in nicely. As stated, you need to drill a hole in the bar for the gimble bearing driver, the directions are not clear, what I did was before I take out the old gimble bearing, put an O ring on the bar close to the last step on the bar, slide the bar all the way in, then carefully slide the bar out, this marks the distance from the back of the gimble bearing to where the shaft on the outdrive bottoms out, move the O ring a 1/4” towards the stepped part of the alignment tool (this is so you won’t bottom out the alignment tool when driving the gimble bearing in) then slide the driver puck up to the O ring and use a 3/8” diameter transfer punch through the side hole in the puck to mark the bar. You need to drill a 3/8” diameter hole in the alignment bar, two V blocks, some clamps, and a drill press will make drilling much easier, after the bar is securely mounted and centered in the drill press, use a center drill, then 1/4” drill first, using plenty of oil, drill all the way through, then use the 3/8” drill, deburr both sides and you should be good to go. People complain that it doesn’t come pre-drilled, the reason is that not all out drives are the same so you have to fit it to the outdrive that you have. Fortunately, I have a machine shop at my house and have a jig setup with various drill bushings, but the method I described above should work for you. Just make sure you’re perfectly centered and secure before you start drilling.
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Reviewed in the United States on April 16, 2026
★★★★★ 5
A must pull your gimbal bearing
You do need to drill a hole but worked perfect
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Reviewed in the United States on December 26, 2025
★★★★★ 5
Worked for Volvo Penta SX Gimbal Bearing
Very heavy tool, I was surprised. Pulled my bearing like it was nothing. Putting the new bearing in was a little more difficult as you have to drill a hole in the engine alignment shaft where it will work for your particular outdrive. Not hard, but it does not come pre-drilled as the required depth for each particular gimbal bearing differs by manufacturer and model. Measure your bearing placement before removal and check that it was installed correctly in the first place. The bearing should line up with the grease fitting and the o-rings on the drive shaft should end up riding in the middle of the bearing. once you have your measurement drill the hole, I used a drill press. I suppose you could use it on multiple outdrive models as long as you can drill more holes.
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Reviewed in the United States on June 5, 2023
★★★★★ 5
Great value
This kit worked perfectly on my Alpha one mercury outdrive. I saw a lot of people mention that it was a hassle to drill the hole when you better have all this alignment stuff. I threw it in use my regular drill drill guide and then the second hole was lined up. Pulling Gimble be very easy. I did have to adjust it up at an angle because my bearing was sitting in their crooked and it came out the second time I made the adjustment to the angle. I would highly recommend this.
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Reviewed in the United States on April 16, 2024
★★★★★ 1
Unfinished product - doesn't work - waste of money
in order to use this as an installation tool the directions tell you to drill a hole through the 2 inch steel rod..... either this hole should already be drilled, or this should not be advertised as an installation tool..... it will not install any bearings without extensive modification and requires the use of a drill press or a lathe. very dissatisfied that I now have to buy ANOTHER tool just to finish this job because this one doesn't do what it's described to do.... piece of junk... typical amazon garbage.... this is why I haven't used amazon in over a year... they rip you off with garbage.... I should have known better .... don't buy this junk .... Now they say 20 -30 days to get my refund .... Don't waste your time
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Reviewed in the United States on May 26, 2026