SKU: 95986887472

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)

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Description

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)Product Specification Host Rabbit Antigen Histone H3 (tri methyl K4) Synonyms H3K4me3 Location Nucleus Accession P68431 Clone Number S 4099 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ChIP Reactivity Hu, Ms, Rt Positive Sample HeLa, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12

Product Specification


Host Rabbit
Antigen Histone H3 (tri methyl K4)
Synonyms H3K4me3
Location Nucleus
Accession P68431
Clone Number S-4099
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC, ChIP
Reactivity Hu, Ms, Rt
Positive Sample HeLa, NIH/3T3, C6
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20°C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
ICC 1:500 Hu, Ms
ChIP 1:20-1:50 Hu

Background

Histone H3 lysine 4 trimethylation (commonly denoted as H3K4me3) is a crucial epigenetic modification on the tail of core histone H3 that plays a central role in regulating gene transcription. It is primarily catalyzed by histone methyltransferases from the COMPASS/COMPASS-like family (such as MLL1-4 and SET1A/B) and is specifically recognized by "reader" proteins containing PHD domains (e.g., Taf3 and ING family proteins). The genomic distribution of H3K4me3 is highly characteristic: it is strongly enriched at the promoter regions of actively transcribed genes, particularly near transcription start sites, marking a "primed for activation" state. This modification facilitates the formation of open chromatin structures and the assembly of the transcription initiation complex by recruiting chromatin remodelers, general transcription factors, and histone acetyltransferases, thereby positively regulating gene expression. H3K4me3 is essential for maintaining pluripotency in embryonic stem cells, cell fate determination, and processes such as learning and memory. Notably, its dysregulation—whether excessive or deficient—is closely associated with various developmental disorders and cancers (such as leukemia and breast cancer). Consequently, H3K4me3 is not only a vital biomarker in fundamental research but also a potential target for disease diagnosis and therapy.

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SKU: 95986887472

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4.5 ★★★★★
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Alien Nomad
Charlottesville, US
★★★★★ 5
Anker 332 USB-C Hub (5-in-1): The Swiss Army Knife of Connectivity
Color: Black
Ever felt like your laptop was playing a cruel joke on you with its lack of ports? Enter the Anker 332 USB-C Hub (5-in-1)—the tech equivalent of a superhero swooping in to save the day (and your productivity). Port Party This hub is like the ultimate party host: it’s got a little something for everyone. Need to connect an external monitor? Boom, there’s a 4K HDMI port. Want to transfer files faster than a cheetah on a caffeine rush? It’s got two 5 Gbps USB-A ports and a 5 Gbps USB-C data port ready to go. Oh, and don’t worry about keeping your laptop charged while you’re multitasking like a boss—there’s a 100W PD-IN port to keep the power flowing. 4K HDMI: Because Why Settle for Less? Let’s talk about that HDMI port, shall we? We’re talking 4K at 30Hz, which means your Netflix binge or work presentation will look crisp, clean, and oh-so-satisfying. It’s like upgrading from VHS to Blu-ray—you won’t believe you ever survived without it. File Transfers in a Flash Remember the days when transferring files felt like waiting for dial-up internet to connect? Yeah, those days are over. With up to 5 Gbps transfer speeds, you can move files so fast that you’ll barely have time to grab your coffee before it’s done. Just think of all the time you’ll save—and how much more you can procrastinate as a result! Pass-Through Charging: Power Up, Don’t Power Down One of the worst feelings in the tech world is watching your battery icon turn red while you’re in the middle of something important. But fear not—this hub’s got you covered with up to 85W pass-through charging. So, go ahead and keep doing whatever it is you’re doing, whether it’s crushing deadlines or browsing cat memes (no judgment here). Compact and Reliable The Anker 332 USB-C Hub is compact enough to slip into your laptop bag without a second thought. And with an 18-month worry-free warranty, it’s clear that Anker has your back—just in case you get a little too enthusiastic with all those ports. Final Thought In a world where laptops keep losing ports faster than you lose socks in the laundry, the Anker 332 USB-C Hub is the perfect solution. It’s reliable, versatile, and just what you need to bring your laptop back to life. So go ahead—plug in, power up, and let the good times (and files) roll!
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Reviewed in the United States on August 20, 2024
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Pratik @ Toronto, CA
Dallas, US
★★★★★ 5
Excellent Product - USB C - power and data transfer!
Color: Black
It works great. I used this to connect two USB-C devices: one from the POS printer and another for charging, both connected to my tablet into one USB-C. It solved the biggest issue that I was facing.
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Reviewed in the United States on April 21, 2026
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John3.16
Grantham, US
★★★★★ 5
Great choicd
Color: Black
Work great, size is compact and out of the way.
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Reviewed in the United States on June 11, 2026
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Magpie
Port Orchard, US
★★★★★ 5
Great replacement screen for an old Chromebook
Size: 15.6" 1080P
Needed a new Screen for an older touch-screen Samsung Chromebook that bit the dust. Repairing it wasn't an option since it's no longer available. Enter this gem of a portable monitor. It works great. Not a replacement touch screen, but works fine with the chromebook touch pad or mouse and dongle. Easy to hook up, a bit testy on first several attempted to bluetooth connect, but works fine now. The speakers leave a bit to be desired, but I just use Bluetooth speakers anyway. Overall, very pleased with the screen clarity and responsiveness of this portable monitor. 15" screen. Great value! I'd buy it again.
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Reviewed in the United States on June 4, 2026
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Michelle
Lexington, US
★★★★★ 5
Exceptional - Better than one twice the price
Size: 15.6" 1080P
I bought a different external monitor a few years ago for twice the price and it was abominable compared to this monitor. This monitor is absolutely perfect. The speakers are definitely tinny like others mentioned, so don't expect to DJ a party with this thing, but for work it's perfect since that means voices are clearer anyways. The sound just isn't as full/rounded with proper bass, but it doesn't even matter because there's also a headphone jack on the monitor, too. USB-C is a total game changer for powering and passing full audio-visual in a single port. The included cables are also a big win since getting a spare data USB-C cable can get pricey and I know the one included is guaranteed to work with this monitor. It was literally plug-and-play with my 2023 16" Macbook Pro. I could go on and on about how every detail of this monitor is perfect, like how the stand is also a screen protector cover and how light and easy it is to carry and how the little grippy feet hold it in place confidently, but my point is THIS is FINALLY the external monitor I've been looking for!!!
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Reviewed in the United States on May 26, 2026

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