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Description
TLR2 Flag-His Tag Protein, Human(SP17)(Detergent)Product Specification Species Human Synonyms toll like receptor 2 Accession O60603 Concentration 0. 13mg ml by Nanodrop Amino Acid Sequence O60603, https: www. uniprot. org uniprotkb O60603 entry Expression System HEK293 Molecular Weight 90 kDa Purity > 90% as determined by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag, Flag Tag Physical Appearance Liquid with detergent Storage Buffer 50 mM Hepes, ph8. 0, 500 mM NaCl, 0. 05%DDM, 0.
Product Specification
| Species | Human |
| Synonyms | toll-like receptor 2 |
| Accession | O60603 |
| Concentration | 0.13mg/ml by Nanodrop |
| Amino Acid Sequence | O60603, https://www.uniprot.org/uniprotkb/O60603/entry |
| Expression System | HEK293 |
| Molecular Weight | 90 kDa |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag, Flag Tag |
| Physical Appearance | Liquid with detergent |
| Storage Buffer | 50 mM Hepes, ph8.0, 500 mM NaCl, 0.05%DDM, 0.01%CHS. |
| Stability & Storage | ·6 months from date of receipt, -60 to -80 °C as supplied. |
| Reference | 1. Jin M S, Kim S E, Heo J Y, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide[J]. Cell, 2007, 130(6): 1071-1082. |
Background
The TLR family of proteins plays a key role in innate immunity by detecting conserved microbial molecular patterns like lipoproteins, lipopolysaccharides, flagellin, and nucleic acids. These type I transmembrane glycoproteins feature a single transmembrane domain and a conserved intracellular domain. TLR2, often paired with TLR1 or TLR6, is crucial for recognizing microbial lipoproteins and lipopeptides, driving inflammatory responses. It's particularly important in combating tuberculosis. Overall, TLR2 is pivotal in multiple physiological processes and holds great promise as a therapeutic target. Developing TLR2-targeted drugs could significantly advance treatments for various diseases.
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