Pay in installments of $61.25 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 15 - Aug 20
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
OSMR/IL-31RB His Tag Protein, HumanProduct Specification Species Human Antigen OSMR IL 31RB Synonyms OSMRB,PLCA1, IL 31RB,OSMR beta,IL 31R beta Accession Q99650 Amino Acid Sequence Glu28 Met740, with C terminal 10*His
Product Specification
| Species | Human |
| Antigen | OSMR/IL-31RB |
| Synonyms | OSMRB,PLCA1, IL-31RB,OSMR beta,IL-31R-beta |
| Accession | Q99650 |
| Amino Acid Sequence | Glu28-Met740, with C-terminal 10*His ERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSMGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 100-120 kDa (Reducing) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Qing Guo, Ge‐fei Guan, Jing‐yuan Cao, Cun‐yi Zou, Chen Zhu, Wen Cheng. Overexpression of oncostatin M receptor regulates local immune response in glioblastoma. OR IGINAL RESEARCH ARTICLE. |
Background
Oncostatin M receptor (OSMR), also named as IL‐31R‐β, is a cytokine receptor gene of IL‐6 family and transduces oncostatin M (OSM) and IL‐31 signaling. A recent study shows that OSMR expression is elevated in GBM, especially mesenchymal subtype. OSM/OSMR signaling has been shown to play an important role in driving the glioma cells towards mesenchymal type, and correlated with poor survival. Moreover, OSMR is a direct transcriptional target gene of STAT3 and forms a physical complex with epidermal growth factor receptor vIII (EGFRvIII), a truncated EGFR in which exons 2−7 are deleted. OSMR also promotes the proliferation of human brain tumor stem cells (BTSCs) and the depletion of OSMR impaired EGFRvIII‐STAT3 signaling. OSMR may be a key factor and related to JAK/STAT signaling in mediating the effect of endogenous bornavirus‐like nucleoprotein elements on the proliferation and apoptosis of oligodendroglia cells.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy