SKU: 99798902218

Mouse Anti-Rat CD45R Antibody (S-3303)

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Description

Mouse Anti-Rat CD45R Antibody (S-3303)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; Ptprc Location Cell membrane, Synapse Accession P04157 Clone Number S 3303 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Rt Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date

Product Specification


Host Mouse
Antigen CD45
Synonyms Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; Ptprc
Location Cell membrane, Synapse
Accession P04157
Clone Number S-3303
Antibody Type Mouse mAb
Isotype IgG2b,k
Application FCM
Reactivity Rt
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Background

CD45R is a critical splice variant of the CD45 protein, belonging to the receptor-type protein tyrosine phosphatase (RPTP) family. It is primarily expressed on the surface of B cells, monocytes, and certain T cell subsets. As a transmembrane glycoprotein, its extracellular region contains domains (A, B, C) encoded by variable exons, forming diverse isoforms (e.g., CD45RA, CD45RB). These domain variations influence glycosylation patterns and ligand-binding properties. The core function of CD45R lies in its intracellular phosphatase domain, which specifically dephosphorylates the C-terminal inhibitory tyrosine residues of Src family kinases (such as Lck and Fyn). This action positively regulates the initiation and activation threshold of lymphocyte receptor signaling pathways, playing a vital role in B cell development, activation, and the fine-tuning of immune responses. Changes in its expression pattern often serve as markers for lymphocyte differentiation and activation status (e.g., CD45RA+ denotes naive T cells), holding significant value in immunology research and the clinical diagnosis of immune-related diseases.

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SKU: 99798902218

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1 star
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