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Description
FGF-17 Protein, MouseProduct Specification Species Mouse Synonyms fgf17b; zgc: 101759 Accession P63075 Amino Acid Sequence Thr23 Thr216 Expression System E. coli Molecular Weight 25kDa (Reducing) Purity 95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 500mM NaCl, pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | fgf17b; zgc:101759 |
| Accession | P63075 |
| Amino Acid Sequence | Thr23-Thr216 |
| Expression System | E.coli |
| Molecular Weight | 25kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 500mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. K Scearce-Levie and E D Roberson (2008) Genes Brain Behav. 7(3):344-54. |
Background
Fibroblast Growth Factors (FGFs) are polypeptides with diverse activities in development and physiology. The mammalian Fgf family can be divided into the intracellular Fgf11/12/13/14 subfamily (iFGFs), the hormone-like Fgf15/21/23 subfamily (hFGFs), and the canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20. Recent evidence suggests that Fgf17 is important in neural patterning. During embryonic development, Fgf17 is expressed in the patterning centers for the rostral forebrain and the midbrain/hindbrain. Studies of Fgf17-deficient mice showed that Fgf17 is required for development of the cerebellar vermis and inferior colliculus and for the regionalization of frontal cortex. Fgf17 ablation reduced the size of the dorsal frontal cortex and the extent of frontal cortex projections to subcortical targets.
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