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Description
Biotin Mouse Anti-Mouse CD64 Antibody (S-R614)Product Specification Host Mouse Antigen CD64 Synonyms High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc gamma RI (FcRI); Fcg1; Fcgr1 Location Cell membrane Accession P26151 Clone Number S R614 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Ms Positive Sample RAW 264. 7 Purification Protein G Concentration 0. 5 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD64 |
| Synonyms | High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI (FcRI); Fcg1; Fcgr1 |
| Location | Cell membrane |
| Accession | P26151 |
| Clone Number | S-R614 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | RAW 264.7 |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
CD64, also known as Fc-gamma receptor I (FcγRI), is a 72-kDa type I transmembrane glycoprotein encoded by the FCGR1A gene on chromosome 1. It belongs to the immunoglobulin superfamily and is composed of three extracellular Ig-like C2-type domains, a single transmembrane region, and a short cytoplasmic tail that associates with the Fc receptor γ-chain containing an ITAM motif to mediate intracellular signaling. CD64 is constitutively expressed on monocytes, macrophages, and dendritic cells, and can be rapidly up-regulated on neutrophils by pro-inflammatory stimuli such as IFN-γ, LPS, or G-CSF. It functions as a high-affinity receptor for the Fc portion of IgG, particularly IgG1 and IgG3, enabling key immune processes including phagocytosis, antigen presentation, antibody-dependent cellular cytotoxicity (ADCC), and the release of reactive oxygen species and cytokines. Its expression is tightly linked to innate immune activation, making CD64 a sensitive biomarker for bacterial infections and inflammatory disorders such as sepsis and rheumatoid arthritis.
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Exchange/Return Notes
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