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Description
DCAF8 Recombinant Rabbit mAb (S-3483-11)Product Specification Host Rabbit Antigen DCAF8 Synonyms DDB1 and CUL4 associated factor 8; WD repeat containing protein 42A; H326; WDR42A Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q5TAQ9 Clone Number S 3483 11 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample HeLa, 293T, THP 1, SK BR 3, DU 145, HL 60, Raji Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | DCAF8 |
| Synonyms | DDB1- and CUL4-associated factor 8; WD repeat-containing protein 42A; H326; WDR42A |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q5TAQ9 |
| Clone Number | S-3483-11 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, 293T, THP-1, SK-BR-3, DU 145, HL-60, Raji |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
| IHC-P | 1:2000 | Hu |
| ICC | 1:500 | Hu |
Background
DCAF8 (DDB1- and CUL4-associated factor 8), also known as WDR42A, is a WD40-repeat β-propeller protein that serves as a substrate receptor for the CUL4-DDB1-ROC1 E3 ubiquitin ligase complex, thereby directing ubiquitination and proteasomal degradation of specific targets to regulate cell-cycle progression, DNA-damage response, transcription, spermatogenesis and muscle atrophy, and its dysfunction is linked to male infertility, hereditary motor and sensory neuropathy with giant axons, and cancer.
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