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Description
Alexa Fluor 647-Labeled CD20 Flag&His Tag Full Length Protein, Human (Detergent)Product Specification Species Human Synonyms B lymphocyte surface antigen B1MS4A1B lymphocyte antigen CD20Membrane Spanning 4 Domains A1Leukocyte Surface Antigen Leu 16CD20 AntigenCD20Bp35Membrane Spanning 4 Domains Subfamily A Member 1CD20 ReceptorLEU 16CVID5MS4A2B1S7Antigens CD20Membrane Spanning 4 Domains Subfamily A Member 1B Lymphocyte Cell Surface Antigen B1 Accession P11836 Amino Acid Sequence Full length, with Flag tag at N Terminus, and His
Product Specification
| Species | Human |
| Synonyms | B-lymphocyte surface antigen B1，MS4A1，B-lymphocyte antigen CD20，Membrane Spanning 4-Domains A1，Leukocyte Surface Antigen Leu-16，CD20 Antigen，CD20，Bp35，Membrane-Spanning 4-Domains Subfamily A Member 1，CD20 Receptor，LEU-16，CVID5，MS4A2，B1，S7，Antigens， CD20，Membrane-Spanning 4-Domains， Subfamily A， Member 1，B-Lymphocyte Cell-Surface Antigen B1 |
| Accession | P11836 |
| Amino Acid Sequence | Full length, with Flag tag at N-Terminus, and His tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 35.4 kDa |
| Conjugation | Alexa Fluor® 647 |
| Tag | His Tag, Flag Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 25mM Hepes,150mM NaCl,0.02%DDM |
| Stability & Storage |
· 16 months from date of receipt stored at -80℃. |
| Reference | 1. Rougé L, Chiang N, Steffek M, et al. Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab[J]. Science, 2020, 367(6483): 1224-1230. |
Background
CD20 is a 33-37 kDa non-glycosylated protein present on the surface of normal and malignant B lymphocytes and is a member of the MS4A (membrane-spanning 4-domain family A) protein family. The CD20 protein comprises four hydrophobic transmembrane domains, one intracellular domain, and two extracellular domains (a large loop and a small loop), with both the N- and C-termini located within the cytosol. CD20 is associated with several key molecules, including the major histocompatibility complex class II (MHCII), CD40 molecule, B-cell receptor (BCR), and the C-terminal src kinase-binding protein (CBP). CBP interacts with Src kinases such as LYN, FYN, and LCK.A deficiency in CD20 has been shown to result in a reduced number of circulating memory B cells, decreased isotype switching of immunoglobulins (Ig), and lower IgG antibody levels. It is also linked to various pathophysiological diseases and disorders.CD20 plays a crucial role in multiple physiological processes and is thus a promising therapeutic target. The CD20 protein product has the potential to enhance drug discovery efforts in related fields.
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4.7 ★★★★★
Based on 26 reviews
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Product Reviews
★★★★★ 5
Perfect in every way!
We love this king size comforter. It is so soft and NO NOISE when touching or moving it around. It has just enough fill to keep us both warm. Just like we like it. We replaced this with one that was way to thick and way to heavy. This one is very high quality with good distributed fill in each pocket. We wanted to buy one for our grandsons twin bed, but unfortunately they only had Queen up to Cali King. He fell in love with how soft and warm it was, without being too hot also. It took about 6 hours to fill out from unpacking and it’s again perfect. Not paper thin and not aggravatingly thick either. Just right! Now I can watch TV while laying down in bed without having to move the comforter every 5 minutes.
We have had many all season comforters over the years from bargain priced to $400.00 ones and this is the best one ever. This price point beats the high end ones in every way. Get this I promise you won’t be disappointed. Excellent quality and comfort for the price. A true hidden treasure!
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Reviewed in the United States on December 11, 2024
★★★★★ 5
Snuggled up writing this review!
I love the weight, and puff to this lovely comforter! It does keep me warm, and I have NOT noticed any noise.. I'm not sure what others were talking about about. I love how soft but well made this is made! I recommend this if you're looking to dip your toes into a down comforter ...or just want to feel luxurious!
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Reviewed in the United States on November 1, 2024
★★★★★ 5
Disappointed at first
When comforter arrived in vacuum sealed bag and didn't "fluff" after 24 hours on guest bed, I put it in dryer on refresh. Still not kind of loft I expected.
I put a duvet on it and used it. What a great surprise. It is so warm and now very fluffy. For the Price point of this comforter, I highly recommend it.
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Reviewed in the United States on November 1, 2024
★★★★★ 4
Very nice but….
I love the softness, quality, and feel of the product (feels crispy?? Not sure that’s the right word but it’s good). The comforter has a tiny bit of noise but I wasn’t bothered.
Now… I am a huge fan of fluffiness and this just quite didn’t get as fluffy as I had hoped (compared to my other one) so I deducted one star. I kept shaking and fluffing and finally I put in the dryer. First I put on low tumble as suggested and that did absolutely nothing. So then I put another time in the dryer at regular heat and that helped some. I suspect ( but don’t know yet) this could fill out with time.
So I will keep the item and we’ll see if I buy another one. I love to put down comforters in my guest rooms so my guests feel like they’re in a hotel on vacation. It’s my treat to friends/family.
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Reviewed in the United States on December 4, 2024
★★★★★ 5
Very, very comfortable and perfect weight.
It is a wonderful comforter, takes about ten days for it to fluff back to normal after shipping. I have not slept so go in months.
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Reviewed in the United States on March 19, 2025