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Description
GFAP Recombinant Rabbit mAb (SDT-1561-14)Product Specification Host Rabbit Antigen GFAP Synonyms Glial fibrillary acidic protein; GFAP Immunogen Recombinant Protein Accession P14136 Clone Number SDT 1561 14 Antibody Type Recombinant mAb Isotype IgG Application CLIA, Sandwich ELISA Reactivity Hu, Ms Cross Reactivity No cross reactivity against NFL, UCHL 1, Tau 441, S100B Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | GFAP |
| Synonyms | Glial fibrillary acidic protein; GFAP |
| Immunogen | Recombinant Protein |
| Accession | P14136 |
| Clone Number | SDT-1561-14 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | CLIA, Sandwich ELISA |
| Reactivity | Hu, Ms |
| Cross Reactivity | No cross-reactivity against NFL, UCHL-1, Tau-441, S100B |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Human glial fibrillary acidic protein (GFAP) is a 432-amino acid long polypeptide encoded by the corresponding gene on chromosome 17q21. It belongs to the type-III intermediate filaments and is responsible for maintaining the mechanical strength of astrocytes which support and regulate the blood-brain barrier. Moreover, GFAP is involved in fundamental and critical astrocytic functions like motility, proliferation, synaptic plasticity, myelination and responses to brain damage. GFAP is highly but not exclusively expressed in astrocytes in the central nervous system (CNS). GFAP has recently drawn attention due to its potential as a promising biomarker for several neurological disorders where it has been shown to have value in disease diagnosis as well as disease progression and treatment monitoring. Several studies have demonstrated elevated GFAP levels in Alzheimer’s disease (AD). Furthermore, blood GFAP levels seem to increase more than 10 years before symptom onset in genetic AD patients. In addition, blood GFAP levels might be able to predict the conversion from AD mild cognitive impairment to AD dementia. In multiple sclerosis (MS) GFAP levels vary by MS subtype and may be used as disease severity and progression biomarker.
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