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Description
Tenascin C Recombinant Rabbit mAb (S-775-274)Product Specification Host Rabbit Antigen Tenascin C Synonyms Tenascin; TN; Cytotactin; GMEM; GP 150 225; Glioma associated extracellular matrix antigen; Hexabrachion; HXB; TNC Immunogen Synthetic Peptide Location Secreted Accession P24821 Clone Number S 775 274 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample U 87 MG, mouse brain, normal mouse E14 foetal brain, normal rat E14 foetal brain
Product Specification
| Host | Rabbit |
| Antigen | Tenascin C |
| Synonyms | Tenascin; TN; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; HXB; TNC |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P24821 |
| Clone Number | S-775-274 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | U-87 MG, mouse brain, normal mouse E14 foetal brain, normal rat E14 foetal brain |
| Predicted Reactivity | Pg |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:100-1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
Tenascin-C (TNC) is a large, multimodular, extracellular matrix glycoprotein that exists in several molecular forms (180-250 kDa) due to alternative splicing and protein modifications. It is a hexameric protein with each subunit having a molecular weight of around 300 kDa. TNC has a restricted pattern of expression but performs a wide range of functions. It plays crucial roles in cell proliferation, migration, and adhesion modulation, inhibiting cellular adhesion to fibronectin. It is highly expressed during embryonic development, tissue remodeling, wound healing, inflammation, and cancer progression. TNC also regulates immune responses and is involved in both innate and adaptive immunity. Additionally, it has binding partners like fibronectin, collagen, and proteoglycans, and its expression is tightly controlled by various transcription factors and intracellular regulators.
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Exchange/Return Notes
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