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Description
Human IL-4 OneStep ELISA KitProduct Specification Antigen IL 4 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 2 to 8 C as supplied. Kit Precision Intra assay: 4. 1% Inter assay: 4. 4% Sample type Cell culture supernatant, Serum, Plasma Assay type Sandwich (quantitative) Sensitivity 0. 435 pg ml Range 1. 25 pg mL 80 pg mL Recovery Cell culture supernatant: 87% Serum: 111% Plasma: 116% Assay time 60 minutes
Product Specification
| Antigen | IL-4 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 2 to 8 °C as supplied. |
Kit
| Precision | Intra-assay: 4.1%； Inter-assay: 4.4% |
| Sample type | Cell culture supernatant, Serum, Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.435 pg/ml |
| Range | 1.25 pg/mL – 80 pg/mL |
| Recovery | Cell culture supernatant: 87% Serum: 111% Plasma: 116% |
| Assay time | 60 minutes |
| Species reactivity | Human |
| NIBSC convert | The dose response curve of the International Standard (88/656) parallels the OneStep standard curve. To convert sample values obtained with the kit to approximate NIBSC (88/656) units, use the following equation: NIBSC (88/656) approximate value (IU/mL) = 0.01 x OneStep Human IL-4 value (pg/mL). |
Background
Interleukin 4(IL4) was first identified as a helper T cell product with the capacity to co-stimulate B cell growth in vitro. IL-4 also can rescue B-cells from apoptosis, enhancing their survival, and is responsible for immunoglobulin isotype switching to IgG1 and IgE. The effect of IL-4 signaling is mediated through the IL-4 receptor alpha chain (IL-4Rα). Upon binding to its ligand, IL-4Rα dimerizes either with the common gamma chain (γc) to produce the type-1 signaling complex located mainly on hematopoietic cells, or with the IL-13 receptor alpha 1 (IL-13Rα1) to produce the type-2 complex, which is expressed also on non-hematopoietic cells. The type-1 signaling complex is critical for Th2-skewing of T cells and the development of alternatively activated macrophages (AAMΦs), while the type-2 complex plays a role in non-hematopoietic responses to IL-4 and IL-13.
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