SKU: 34317436593

CaV2.3 (CACNA1E) Recombinant Rabbit mAb (S-3244-59)

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Description

CaV2.3 (CACNA1E) Recombinant Rabbit mAb (S-3244-59)Product Specification Host Rabbit Antigen CaV2. 3 (CACNA1E) Synonyms Voltage dependent R type calcium channel subunit alpha 1E; Brain calcium channel II (BII); Calcium channel; L type; alpha 1 polypeptide; isoform 6; Voltage gated calcium channel subunit alpha Cav2. 3; CACH6; CACNL1A6 Immunogen Synthetic Peptide Location Membrane Accession Q15878 Clone Number S 3244 59 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt

Product Specification


Host Rabbit
Antigen CaV2.3 (CACNA1E)
Synonyms Voltage-dependent R-type calcium channel subunit alpha-1E; Brain calcium channel II (BII); Calcium channel; L type; alpha-1 polypeptide; isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3; CACH6; CACNL1A6
Immunogen Synthetic Peptide
Location Membrane
Accession Q15878
Clone Number S-3244-59
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Ms, Rt
Positive Sample mouse brain, rat brain
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000 Ms, Rt
IHC-P 1:2000 Ms, Rt

Background

CaV2.3, encoded by the CACNA1E gene, is a member of the high-voltage-activated (HVA) R-type calcium channel family, distinguished by its unique biophysical properties including rapid activation and inactivation kinetics, single-channel conductance, and insensitivity to conventional dihydropyridine, ω-conotoxin GVIA, or ω-agatoxin IVA blockers. Predominantly expressed in the central nervous system—particularly in the cortex, hippocampus, cerebellum, and thalamus—this channel plays a critical role in regulating neuronal excitability, neurotransmitter release at specialized synapses, and synaptic plasticity. Functionally, CaV2.3 channels contribute to action potential repolarization, afterhyperpolarization, and pacemaking activities in specific neuronal populations, while also modulating calcium signaling pathways that influence gene transcription and neuronal survival. Clinically, gain-of-function mutations in CACNA1E have been associated with developmental and epileptic encephalopathies, autism spectrum disorders, and chronic pain conditions, whereas the channel represents a potential therapeutic target for epilepsy, neuropathic pain, and neurodegenerative diseases due to its distinct pharmacological profile and restricted neuronal distribution.

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SKU: 34317436593

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lojo
Chelsea, US
★★★★★ 4
Cute but not hinged at arms
Color: Porcini Tortoise, Size: 52-17-140
They were cute. I didn’t like that they weren’t hinged. They were harder to open and close. I didn’t look for this feature before I purchased.
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Reviewed in the United States on February 3, 2026
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Grantham, US
★★★★★ 5
Anteojos modernos.
Color: Blush Tortoise, Size: Lens-52 Bridge-17 B-37.5 ED-56.1 Temple-140, Color: Blush Tortoise, Size: Lens-52 Bridge-17 B-37.5 ED-56.1 Temple-140
Mis lentes son muy cómodos, y me gustan como lucen, vienen sin medidas yo los adecué con mi Optometrista. Se aflojan con el tiempo, pero compré una pinza que ajusta los tornillos…realmente lucen como nuevos.
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ginger
Port Orchard, US
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The glasses are made well
Color: Pearl Brown Tort, Size: 53-16-135
The glasses fit well and are made well. They are Great value for the money.
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DAVID L.
Battle Creek, US
★★★★★ 5
Nice shoes!
Size: 11, Color: Black Full Grain
I bought them in black and I like them so much I will be buying the brown soon. They fit true to size and are comfortable and stylish. I like the clean simplicity. They're basically a dressy sneaker which is perfect for my job's 'dress code'. Yet they're stylish enough to be worn weekends or a night out. They seemed just a touch stiff out of the box but IMO that's completely normal and fine - after just a couple days of wearing them they are breaking in nicely. No complaints on that. They seem to be of very high quality and I'm very happy with them.
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Bamaphan
Battle Creek, US
★★★★★ 5
Good shoes!!!!!
Size: 10, Color: Tan Full Grain
They are comfortable, they fit, great style. I bought blue, brown and black shoes.
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Reviewed in the United States on August 18, 2025

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