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Description
CaV2.3 (CACNA1E) Recombinant Rabbit mAb (S-3244-59)Product Specification Host Rabbit Antigen CaV2. 3 (CACNA1E) Synonyms Voltage dependent R type calcium channel subunit alpha 1E; Brain calcium channel II (BII); Calcium channel; L type; alpha 1 polypeptide; isoform 6; Voltage gated calcium channel subunit alpha Cav2. 3; CACH6; CACNL1A6 Immunogen Synthetic Peptide Location Membrane Accession Q15878 Clone Number S 3244 59 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt
Product Specification
| Host | Rabbit |
| Antigen | CaV2.3 (CACNA1E) |
| Synonyms | Voltage-dependent R-type calcium channel subunit alpha-1E; Brain calcium channel II (BII); Calcium channel; L type; alpha-1 polypeptide; isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3; CACH6; CACNL1A6 |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | Q15878 |
| Clone Number | S-3244-59 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms, Rt |
| Positive Sample | mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Ms, Rt |
| IHC-P | 1:2000 | Ms, Rt |
Background
CaV2.3, encoded by the CACNA1E gene, is a member of the high-voltage-activated (HVA) R-type calcium channel family, distinguished by its unique biophysical properties including rapid activation and inactivation kinetics, single-channel conductance, and insensitivity to conventional dihydropyridine, ω-conotoxin GVIA, or ω-agatoxin IVA blockers. Predominantly expressed in the central nervous system—particularly in the cortex, hippocampus, cerebellum, and thalamus—this channel plays a critical role in regulating neuronal excitability, neurotransmitter release at specialized synapses, and synaptic plasticity. Functionally, CaV2.3 channels contribute to action potential repolarization, afterhyperpolarization, and pacemaking activities in specific neuronal populations, while also modulating calcium signaling pathways that influence gene transcription and neuronal survival. Clinically, gain-of-function mutations in CACNA1E have been associated with developmental and epileptic encephalopathies, autism spectrum disorders, and chronic pain conditions, whereas the channel represents a potential therapeutic target for epilepsy, neuropathic pain, and neurodegenerative diseases due to its distinct pharmacological profile and restricted neuronal distribution.
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