SKU: 36455986089

Phospho-IRE1 (S724) Recombinant Rabbit mAb (S-3480-15)

Sale price$90.00 Regular price$100.00
Save 10%

Pay in installments of $25.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 9 - Aug 14

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Phospho-IRE1 (S724) Recombinant Rabbit mAb (S-3480-15)Product Specification Host Rabbit Antigen Phospho IRE1 (S724) Synonyms Serine threonine protein kinase endoribonuclease IRE1; Endoplasmic reticulum to nucleus signaling 1; Inositol requiring protein 1 (hIRE1p); Ire1 alpha (IRE1a); IRE1; ERN1 Immunogen Synthetic Peptide Location Nucleus Accession O75460 Clone Number S 3480 15 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms Positive Sample Serum starved and Calyculin A

Product Specification


Host Rabbit
Antigen Phospho-IRE1 (S724)
Synonyms Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1 (hIRE1p); Ire1-alpha (IRE1a); IRE1; ERN1
Immunogen Synthetic Peptide
Location Nucleus
Accession O75460
Clone Number S-3480-15
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC
Reactivity Hu, Ms
Positive Sample Serum-starved and Calyculin A treated HeLa, Calyculin A treated NIH/3T3
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
Dot Blot 1:1000
WB 1:1000 Hu, Ms
ICC 1:100 Hu

Background

Phospho-IRE1 (S724) refers to the phosphorylated form of inositol-requiring enzyme 1-alpha (IRE1α) at serine residue 724, a critical post-translational modification that serves as a hallmark of IRE1α activation during the unfolded protein response (UPR). As an endoplasmic reticulum (ER) transmembrane protein kinase and endoribonuclease, IRE1α remains in an inactive, monomeric state under basal conditions through binding to the ER chaperone BiP/GRP78; however, upon accumulation of misfolded proteins within the ER lumen, dissociation from BiP triggers oligomerization and trans-autophosphorylation at multiple sites including S724 within its kinase activation loop. This phosphorylation event induces a conformational shift that licenses the RNase domain to excise a 26-nucleotide intron from X-box binding protein 1 (XBP1) mRNA, yielding the potent transcription factor XBP1s that upregulates ER-associated degradation (ERAD) machinery, chaperone expression, and phospholipid synthesis to restore proteostasis. Beyond XBP1 splicing, phospho-IRE1 (S724) also regulates the selective degradation of specific mRNAs and microRNAs through regulated IRE1-dependent decay (RIDD), modulating cellular outcomes ranging from survival to apoptosis depending on stress intensity and duration. Dysregulation of IRE1α phosphorylation at this site has been implicated in diverse pathologies including multiple myeloma, diabetes, neurodegenerative disorders, and inflammatory conditions, making S724-phosphorylated IRE1 a valuable biomarker for ER stress levels and an attractive therapeutic target for small molecule kinase inhibitors aimed at modulating the UPR signaling cascade.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 36455986089

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.2 ★★★★★
Based on 27 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
J
Verified Purchase
Jewels8273
Pawtucket, US
★★★★★ 5
Helping my daily work life!
Color: Black
This has minimized my arm, wrist and hand pain. It’s soft, sturdy and stays in place. Reasonable price and would recommend if you want something with solid quality.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 26, 2026
T
Verified Purchase
Truth lies here
New York, US
★★★★★ 5
Good thick cushion
Color: Black Set
Thick and comfortable
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 5, 2026
C
Verified Purchase
Courtney Eden
Lexington, US
★★★★★ 5
Great product
Color: Purple Set
Saved my wrists from a lot of pain
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 19, 2026
O
Verified Purchase
OhioD
West Palm Beach, US
★★★★★ 3
Color sub-par
Color: Purple Set
I ordered the purple (lavendar) it looks like it's WHITE. Very pale.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 6, 2026
D
Verified Purchase
Dennis B Higgins
Waukegan, US
★★★★★ 5
Just what I needed
Color: Black
This keyboard pad has been everything I expected it to be. Soft yet firm enough for my wrists, simple yet elegant design and reasonably priced. At some point when it wears down I do plan to purchase again.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 5, 2026

recommand products