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Description
IL-4R alpha/CD124 His Tag Protein, MouseProduct Specification Species Mouse Synonyms IL 4R alpha, CD124, IL4R, IL4RA Accession P16382 Amino Acid Sequence Ile26 Arg233, with C terminal 8*His IKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRGGGSHHHHHHHH Expression System HEK293 Molecular Weight 35 45kDa Purity >95% by SDS PAGE Endotoxin
Product Specification
| Species | Mouse |
| Synonyms | IL-4R alpha, CD124, IL4R, IL4RA |
| Accession | P16382 |
| Amino Acid Sequence | Ile26-Arg233, with C-terminal 8*His IKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Nelms K. et al. (2003) The IL-4 receptor: signaling mechanisms and biologic functions. Annual Review of Immunology. 17: 701-738. |
Background
IL-4Rα is a member of the hematopoietin receptor superfamily. Among the defining features of the members of this superfamily of receptors are shared structural motifs in the extracellular region, which consists of type III fibronectin domains. These motifs include conserved paired Cys residues and, in the membrane proximal region, a WSXWS motif. The latter has been proposed to be required for maintaining the receptor in a conformation favorable to cytokine binding. Structural alterations in the IL-4Rα extracellular region may result in altered receptor signaling capabilities. Indeed, a variant of the human IL-4Rα chain containing a Ile50Val substitution was isolated from atopic individuals and has been shown to enhance signal transduction resulting in the increased production of IgE.
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4.8 ★★★★★
Based on 18 reviews
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Product Reviews
★★★★★ 5
Soooooo comfy!!!
Team Name: Cooling Comforter, Size: King(104"x90"), Color: 01cream White
THE best cooling comforter Ive purchased! It’s so soft and smooth and has just enough weight to it for comfort but still light enough. I’m def buying more!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 14, 2026
★★★★★ 5
Coolest sleep ever
Team Name: Cooling Comforter, Size: King(104"x90"), Color: 01grey
This thing is awesome, I can wrap my whole body up and still have plenty of comforter left. Keeps me nice and cool no more night sweats. Perfect thickness and you cant beat the price. Absolutely love the color fit perfectly with my room and colors already.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 4, 2026
★★★★★ 4
Wonderful
Team Name: Cooling Comforter, Size: Full/Queen(90"x90"), Color: 01blue
Works wonders for cooling! Very breathable. It’s “slick” so slides off the bed overnight if you move a lot in your sleep.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 22, 2026
★★★★★ 5
Perfect for temperature rioting partners lol
Team Name: Cooling Comforter, Size: King(104"x90"), Color: 01grey
Awesome material exactly what I was looking for. Definitely stays cold. It’s perfect for my bf and he can now stay on his side of the bed with his blanket and stop turning the ac on lol
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 24, 2026
★★★★★ 5
THE BESTTTT!
Team Name: Cooling Comforter, Size: King(104"x90"), Color: 01cream White
The BEST cooling blanket i have ever owned. it’s not too heavy or light. it doesn’t pile after washing a few times. I can not sleep without it. i have bought this for several family member’s and for my son and all say it’s be best blanket they have owned. BUY IT!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 25, 2026
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