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Description
TIMP1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms TIMP1, CLGI, TIMP Accession P01033 Amino Acid Sequence Cys24 Ala207, with N terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | TIMP1, CLGI, TIMP |
| Accession | P01033 |
| Amino Acid Sequence | Cys24-Ala207, with N-terminal Human IgG1 Fc DKTHTSPPSPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGSGGGSGGGSGGGSGGGSDDDDKCTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA |
| Expression System | HEK293 |
| Molecular Weight | 55-65kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Hornebeck W. (2004) Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. Pathol Biol. 51(10): 569-573. 2、Soini Y. et al. (2001) Expression of MMP2, MMP9, MT1-MMP, TIMP-1, and TIMP2 mRNA in valvular lesions of the heart. J Pathol. 194(2): 225-231. |
Background
TIMP metallopeptidase inhibitor 1 is also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. TIMP1 is a glycoprotein with a molecular mass of 28 kDa produced by a wide range of cell types. Tissue inhibitor matrix metalloproteinase 1 (TIMP1), which belongs to TIMP gene family, is a natural inhibitor of the matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic tumors. Male-specific up-regulation of systemic TIMP1 was demonstrated in PC mouse models and patients. Using TIMP1-competent and TIMP1-deficient PC mouse models, we established a causal role of TIMP1 in determining shortened survival and increased liver metastasis in males.
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4.4 ★★★★★
Based on 13 reviews
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Product Reviews
★★★★★ 4
Great Book.
Format: Mass Market Paperback
Its great to be able to go back and read Stokely Carmichael today in his own words. This book provides an excellent overview of what black power means and how the concept originated. Although the book seems a bit dated today, many of the ideas presented are still entirely relevant.
Ive only given the book four stars due to its age. Many of the statistics presented are dated, and undoubtedly there are other texts available today that present these ideas in a much better/newer way. But if you are interested in Stokely Carmichael and what he stood for, this is the book to read.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 10, 2012
★★★★★ 5
The paperback was in great shape. I bought one for a friend.
Format: Paperback
There was nothing to dislike about the condition of the book or the shipping. It was on time.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 25, 2024
★★★★★ 5
Excellent articulation of the Black Power initiative within the Civil ...
Format: Paperback
Excellent articulation of the Black Power initiative within the Civil Rights Movement. A detailed view of Black Power, it's objectives, how these would be achieved, as well as it's misinterpretations.
An afterword from each author appended in 1992 provides insight, reflection, and perspective on all that's changed, and what hasn't, since the book's publishing.
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Reviewed in the United States on May 25, 2017
★★★★★ 5
Get one while you can
Format: Mass Market Paperback
Any book with the name Stokely Carmichael is a rare find. You can easily find the same book with Kwame Ture as the author since he changed his name and so later editions reflects the name change. Kwame Ture (fka Stokely Carmichael) changed his name for a reason. However, those of us from the sixties can never forget him nor the name Stokely Carmichael.
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Reviewed in the United States on March 4, 2013
★★★★★ 5
amazing book
Format: Kindle
I enjoyed every bit of it and it has truly blessed my ministry and work toward an alternative community for our local church.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 17, 2026
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