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Description
IκBβ Recombinant Rabbit mAb (S-810-203)Product Specification Host Rabbit Antigen IB Synonyms NF kappa B inhibitor beta; NF kappa BIB; I kappa B beta (IkB B; IkB beta; IkappaBbeta); Thyroid receptor interacting protein 9 (TR interacting protein 9; TRIP 9); NFKBIB; IKBB; TRIP9 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q15653 Clone Number S 810 203 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms Positive Sample Jurkat, HeLa, PANC 1, HDLM
Product Specification
| Host | Rabbit |
| Antigen | IκBβ |
| Synonyms | NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta (IkB-B; IkB-beta; IkappaBbeta); Thyroid receptor-interacting protein 9 (TR-interacting protein 9; TRIP-9); NFKBIB; IKBB; TRIP9 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q15653 |
| Clone Number | S-810-203 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | Jurkat, HeLa, PANC-1, HDLM-2, MCF7, A20, EL4, mouse kidney |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| ICC | 1:500 | Hu |
Background
IκBβ is a member of the IκB family of proteins, which play a crucial role in regulating the activity of NF-κB transcription factors. IκBβ, like IκBα, can sequester NF-κB dimers in the cytoplasm, preventing their translocation to the nucleus and thus inhibiting the expression of NF-κB-dependent genes. Upon stimulation by lipopolysaccharide (LPS), IκBβ is slowly degraded and re-synthesized as a hypophosphorylated form that can enter the nucleus. This nuclear IκBβ can bind to NF-κB dimers such as p65:c-Rel, stabilizing them and promoting the expression of specific pro-inflammatory genes like TNF-α. Interestingly, IκBβ−/− mice show a dramatic reduction in TNF-α production in response to LPS and are resistant to LPS-induced septic shock and collagen-induced arthritis. This suggests that IκBβ not only acts as an inhibitor of NF-κB but also as a positive regulator of certain NF-κB-dependent genes, highlighting its dual role in the inflammatory response.
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