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Description
HRSV(Strain A2)Nucleoprotein,His Tag ProteinProduct Specification Species HRSV Synonyms Nucleoprotein, Protein N, Nucleocapsid protein Accession P03418 Amino Acid Sequence
Product Specification
| Species | HRSV |
| Synonyms | Nucleoprotein, Protein N, Nucleocapsid protein |
| Accession | P03418 |
| Amino Acid Sequence | MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVELHHHHHHHH |
| Expression System | E.coli |
| Molecular Weight | 45kDa |
| Purity | >95% by SDS-PAGE&HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 150mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Oliveira A P. et al. (2013) Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells. Virus Res. 177(1): 108-112. 2、Céspedes P F. et al. (2014) Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells. Proc Natl Acad Sci USA. 111(31): 3214-3223. |
Background
Human Respiratory Syncytial Virus (HRSV) is a negative-sense single-stranded RNA virus that belongs to the Paramyxoviridae family and the Pneumovirinae subfamily, and considered the most important pathogen causing respiratory disease in infants and neonates worldwide. The nucleoprotein of HRSV, a canonical cytosolic protein, is highly conserved among pneumoviruses and interacts with viral RNA, generating a helicoidal nucleocapsid which is responsible for genome and anti-genome resistance to RNAse. In addition, the nucleoprotein could be responsible for inhibiting T-cell activation during infection by HRSV, and expressed on the surface of epithelial and dendritic cells, preventing immunological synapse assembly by naïve CD4+ T cells. Therefore, this protein is defined as a major virulence factor that contributes to impairing acquired immunity and enhances susceptibility to reinfection by HRSV.
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