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Description
alpha smooth muscle Actin (acetyl E3) + ACTG2 (acetyl E3) Recombiant Rabbit mAb (S-3355)Product Specification Host Rabbit Antigen alpha smooth muscle Actin (acetyl E3) + ACTG2 (acetyl E3) Synonyms Actin, aortic smooth muscle; Alpha actin 2; Cell growth inhibiting gene 46 protein; ACTSA; ACTVS; ACTA2; Actin, gamma enteric smooth muscle; Alpha actin 3; Gamma 2 actin; Smooth muscle gamma actin; ACTG2; ACTA3; ACTL3; ACTSG Location Cytoplasm, Cytoskeleton Accession P62736 P63267 Clone Number S 3355 Antibody Type Recombinant mAb Isotype IgG
Product Specification
| Host | Rabbit |
| Antigen | alpha smooth muscle Actin (acetyl E3) + ACTG2 (acetyl E3) |
| Synonyms | Actin, aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein; ACTSA; ACTVS; ACTA2; Actin, gamma-enteric smooth muscle; Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin; ACTG2; ACTA3; ACTL3; ACTSG |
| Location | Cytoplasm, Cytoskeleton |
| Accession | P62736、 P63267 |
| Clone Number | S-3355 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | A431, HeLa, MCF7, NIH/3T3, C6, PC-12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:4000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms, Rt |
Background
Alpha smooth muscle actin (alpha-SMA, acetyl E3) and ACTG2 (actin gamma 2, acetyl E3) are two important actin isoforms primarily involved in smooth muscle cell contraction and cytoskeletal maintenance. Alpha-SMA is a key component of the contractile apparatus in muscle tissues, particularly abundant in vascular, gastrointestinal, and urinary tract smooth muscles. Its acetylation modification (acetyl E3) may influence its function or stability. ACTG2 (γ2-actin) is a smooth muscle-specific γ-actin predominantly expressed in visceral smooth muscles, such as those in the intestines, and its acetylation (acetyl E3) also plays a role in cell motility and structural support. Studies indicate that both proteins can be detected by specific antibodies (e.g., Abcam's [E184] antibody) in immunohistochemistry, with α-SMA showing potential in inhibiting scar formation in fibroblast contraction assays. Their genes and protein structures are highly conserved, and they functionally cooperate in regulating mechanical contraction and cellular morphology in smooth muscle.
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