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Description
GATA3 Recombinant Mouse mAb (SDT-3180)Product Specification Host Mouse Antigen GATA3 Synonyms Trans acting T cell specific transcription factor GATA 3; GATA binding factor 3 Location Nucleus Accession P23771 Clone Number SDT 3180 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample T 47D, EL4 Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%
Product Specification
| Host | Mouse |
| Antigen | GATA3 |
| Synonyms | Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3 |
| Location | Nucleus |
| Accession | P23771 |
| Clone Number | SDT-3180 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | T-47D, EL4 |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:4000 | Hu, Ms, Rt |
Background
GATA3 (GATA-binding protein 3) is a zinc-finger transcription factor encoded by the GATA3 gene on chromosome 10p15 that orchestrates embryogenesis, cell fate, and differentiation across epithelial, endothelial, hematopoietic, and neural lineages by binding the consensus WGATAR DNA motif, and its indispensable roles in mammary luminal specification, T-helper-2 immune responses, parathyroid and inner-ear development are underscored by the severe multi-organ defects seen in Gata3-haploinsufficient HDR syndrome, while in cancer its context-dependent function manifests as an estrogen-receptor-coactivating oncogene in luminal breast tumors and a lineage-survival oncogene in urothelial carcinomas, yet also as a tumor suppressor in some contexts, making immunohistochemical GATA3 positivity a widely used diagnostic biomarker for carcinomas of breast and urothelial origin and a potential therapeutic target whose modulation is being explored with small-molecule inhibitors and epigenetic strategies.
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