MTCO2 Recombinant Rabbit mAb (S-1891-72)

MTCO2 (Mitochondrially Encoded Cytochrome C Oxidase II, also known as COX2 or COII) is a ~25 kDa protein encoded by the mitochondrial genome and embedded in the inner mitochondrial membrane as one of the three mitochondrially-encoded core subunits of cytochrome c oxidase (Complex IV), the terminal enzyme complex of the electron transport chain. This protein plays a critical role in aerobic respiration by mediating the transfer of electrons from cytochrome c to molecular oxygen via its binuclear copper A center (CuA), ultimately catalyzing the reduction of oxygen to water while contributing to the generation of the proton gradient essential for ATP synthesis through oxidative phosphorylation. Highly expressed in energy-demanding tissues such as cardiac muscle, skeletal muscle, and neurons, MTCO2 functions as a pivotal component of the respiratory chain, and its mutations or dysfunctions have been implicated in various mitochondrial disorders, including mitochondrial myopathy, Leber's hereditary optic neuropathy, and other conditions arising from compromised oxidative phosphorylation and cellular energy failure.