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Description
HLA-DRA Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen HLA DR Synonyms HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; HLA DRA1; HLA DRA Immunogen Recombinant Protein Location Cell membrane, Endoplasmic reticulum membrane Accession P01903 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample Raji, Ramos, HuT 78 Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | HLA-DR |
| Synonyms | HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; HLA-DRA1; HLA-DRA |
| Immunogen | Recombinant Protein |
| Location | Cell membrane, Endoplasmic reticulum membrane |
| Accession | P01903 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | Raji, Ramos, HuT-78 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
HLA-DR is a subtype of the human leukocyte antigen (HLA) complex, specifically classified as a class II molecule, and is encoded by genes located on chromosome 6. It plays a crucial role in the immune system by presenting peptide antigens to CD4+ T cells, which subsequently trigger adaptive immune responses, including the activation of B cells and the production of antibodies. HLA-DR is primarily expressed on antigen-presenting cells such as macrophages, dendritic cells, and B cells, and its expression levels can indicate the degree of immune system activation. This molecule is also significant in clinical settings, as it is associated with various autoimmune diseases (e.g., rheumatoid arthritis linked to HLA-DR4) and is a key factor in determining the success of organ transplants. Additionally, HLA-DR has been studied in the context of cancer immunotherapy, where its expression on tumor cells can influence the effectiveness of immune-mediated tumor suppression.
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Exchange/Return Notes
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