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Description
DNAM-1/CD226 His Tag Protein, HumanProduct Specification Species Human Accession Q15762 Amino Acid Sequence Glu19 Asn247, with C terminal 8*His EEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNGGGSHHHHHHHH Expression System HEK293 Molecular Weight 44 57 kDa(Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g
Product Specification
| Species | Human |
| Accession | Q15762 |
| Amino Acid Sequence | Glu19-Asn247, with C-terminal 8*His EEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 44-57 kDa(Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
DNAX accessory molecule 1 (DNAM-1; CD226) is a costimulatory molecule belonging to the immunoglobulin superfamily. DNAM-1 is primarily expressed on NK and CD8 T cells, which has been shown to enhance the cytotoxic effector function of NK cells and T cells against tumor- and virus-infected cells. DNAM-1 is a member of the Ig superfamily, encoded by a gene on human chromosome 18q22.3, is expressed by human NK cells, T cells, a subset of B cells, monocytes and platelets. Interactions between DNAM-1 on NK cells and its ligands on tumour cells augments the NK cell–mediated cytotoxicity and cytokine production. CD155 and its related family member CD112, the known ligands for DNAM-1, broadly expressed on hematopoietic, epithelial, and endothelial cells. Moreover, it was shown that the interaction of DNAM-1 with CD112 and CD155 contributes to the NK-mediated lysis of both imDCs and mDCs. NK cells also express CD96, which shows only ~20% homology to DNAM-1 but was also shown to recongnize CD155 and promote NK cell adhesion and activation. Decreased NK cell activity has been observed in patients with PDAC, and pancreatic cancer patients have less CD226+ NK cells in the blood than do healthy controls. Dysregulation of DNAM-1 is associated with susceptibility to juvenile idiopathic arthritis, type 1 diabetes (T1D), lupus, and rheumatoid arthritis in patients.
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4.6 ★★★★★
Based on 26 reviews
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Product Reviews
★★★★★ 5
Perfect father days gift
Style: Bi-fold
Great quality and perfect size. I made it my dad’s birthday gift and he loved it. And it’s a perfect color and not to thick and looks good.
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Reviewed in the United States on May 1, 2026
★★★★★ 5
It's a wallet alright
Style: Bi-fold
Very good quality
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Reviewed in the United States on June 3, 2026
★★★★★ 4
License flap is terrible, but wallet is nice
Style: Bi-fold
I do like the wallet but I hate the little extra flap inside it. It's very hard to get my license out of it. It makes the wallet way too thick. I just took it out and i don't use it. They should of just sewn 1 flap in there and the wallet would of been much thinner and still able to use the extra flap.
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Reviewed in the United States on May 17, 2026
★★★★★ 5
Excellent and Beautiful Wallet
Style: Bi-fold
Very nice wallet with added protection! Clean look, smooth soft leather, but durable and sturdy. Highly recommend!
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Reviewed in the United States on March 22, 2026
★★★★★ 5
nice quality
Style: Bi-fold
it was a small gift
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Reviewed in the United States on May 27, 2026