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Description
p75 NGF Receptor Recombinant Rabbit mAb(SDT-055-42)Product Specification Host Rabbit Antigen p75 NGF Receptor Synonyms Low affinity neurotrophin receptor p75NTR, Low affinity nerve growth factor receptor, NGF receptor, CD271 Immunogen Synthetic Peptide Location Cytoplasm, Membrane, Intracellular Accession P08138 Clone Number SDT 055 42 Antibody Type Rabbit mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu Predicted Reactivity Ms, Rt Purification Protein A Concentration 0. 5mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | p75 NGF Receptor |
| Synonyms | Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, CD271 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Membrane, Intracellular |
| Accession | P08138 |
| Clone Number | SDT-055-42 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Predicted Reactivity | Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:500 | |
| IHC-P | 1:500 | |
| ICC | 1:500 | |
| WB | 1:1000 |
Background
The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. p75NTR is a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4. All neurotrophins bind to p75NTR. This also includes the immature pro-neurotrophin forms. Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. p75NTR is involved in pathways that promote neuronal survival and neuronal death.
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Exchange/Return Notes
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