Pay in installments of $63.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 17 - Aug 22
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
CD4/LEU3 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD4, LEU3, T4, IMD79, OKT4D Accession P01730 Amino Acid Sequence Lys26 Trp390, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | CD4, LEU3, T4, IMD79, OKT4D |
| Accession | P01730 |
| Amino Acid Sequence | Lys26-Trp390, with C-terminal Human IgG1 Fc KKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 78-84kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Owen G R. et al. (2016) Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2. Biochemistry. 55(15): 2227-2237. |
Background
The cluster of differentiation 4 receptor (CD4) is a 55kDa type I integral membrane glycoprotein which plays a substantial role during adaptive immune responses. In T-cells, CD4 mediates maturation, stabilizes T-cell receptor interactions with peptide-major histocompatibility complex class II (MHCII) complexes on antigen presenting cells, and mediates intracellular T-cell signalling.2 In addition to T-cells, CD4 has also been shown to be expressed on monocytes, monocyte-derived macrophages, Langerhans cells, B lymphocytes, dendritic cells, eosinophils, megakaryocytes and mast cells. The role of CD4 during immune function can also be diverted by the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 as the viral receptor utilizes CD4 as the primary receptor as well as the co-receptor CCR5/CXCR4 during the entry process.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy