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Description
KL Recombinant Rabbit mAb (S-2245-169)Product Specification Host Rabbit Antigen KL Synonyms Klotho Immunogen Synthetic Peptide Location Secreted, Cell membrane Accession Q9UEF7 Clone Number S 2245 169 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Jurkat, K562, mouse kidney, mouse testis, rat kidney, rat testis Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | KL |
| Synonyms | Klotho |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Cell membrane |
| Accession | Q9UEF7 |
| Clone Number | S-2245-169 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Jurkat, K562, mouse kidney, mouse testis, rat kidney, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
KL protein, also known as α-Klotho, is a type-I single-pass transmembrane protein encoded by the KL gene on chromosome 13, featuring a short intracellular tail and a large extracellular region composed of tandem KL1 and KL2 glycosidase-like domains that can be proteolytically cleaved by ADAM10 and other proteases to release a soluble, circulating hormone-like form. Initially discovered as an aging-suppressor, KL functions as a coreceptor for FGF23 to regulate phosphate, calcium, and vitamin D metabolism, while its soluble form modulates insulin/IGF-1 and Wnt signaling, suppresses oxidative stress and inflammation, and enhances synaptic plasticity and cognition; consequently, KL overexpression extends lifespan and improves healthspan in mice, whereas its deficiency accelerates aging phenotypes such as arteriosclerosis, osteoporosis, sarcopenia, and cognitive decline, and human KL variants are associated with hypertension, chronic kidney disease, and age-related disorders .
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