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Description
GRM5 Recombinant Rabbit mAb (SDT-2419-37)Product Specification Host Rabbit Antigen GRM5 Synonyms Metabotropic glutamate receptor 5; mGluR5; GPRC1E Immunogen Synthetic Peptide Location Cell membrane Accession P41594 Clone Number SDT 2419 37 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample mouse brain, mouse hippocampus, rat brain, rat hippocampus Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | GRM5 |
| Synonyms | Metabotropic glutamate receptor 5; mGluR5; GPRC1E |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P41594 |
| Clone Number | SDT-2419-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse brain, mouse hippocampus, rat brain, rat hippocampus |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
GRM5 encodes mGluR5, a Gq-coupled G-protein–coupled receptor selectively expressed at neuronal postsynaptic sites where it senses extracellular glutamate and triggers a phosphatidylinositol-calcium second-messenger cascade that modulates synaptic plasticity and network excitability, thereby influencing cognition, addiction, anxiety and other behaviors, while aberrant GRM5 signaling has been implicated in disorders ranging from schizophrenia and autism spectrum disorder to cancer metastasis and neurodegeneration.
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Exchange/Return Notes
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