SKU: 92111350726

CD40/TNFRSF5 Fc Chimera Protein, Cynomolgus

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Description

CD40/TNFRSF5 Fc Chimera Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50 Accession G7PG38 Amino Acid Sequence Glu21 Arg193, with hIgG1 Fc Expression System HEK293 Molecular Weight 52 58kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Cynomolgus
Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Accession G7PG38
Amino Acid Sequence

Glu21-Arg193, with hIgG1 Fc

Expression System HEK293
Molecular Weight

52-58kDa

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

1、van Kooten C. et al. (2000) CD40-CD40 ligand. J Leukoc Biol. 67(1): 2-17.

2、Bhushan A. et al. (2002) CD40: CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24(3): 311-324.

3、Chatzigeorgiou A. et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-483.

4、Li R. et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-3917.

Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

Background

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Both CD40 and CD40 L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing. CD40 and CD40L are widely expressed in various types of cells, among which B cells and myeloid cells constitutively express high levels of CD40, and T cells and platelets express high levels of CD40L upon activation. CD40L self-assembles into functional trimers which induces CD40 trimerization and downstream signaling. CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate. The mechanisms of benefits include immune cell activation and tumor cell lysis/apoptosis in malignancies, or immune cell inactivation in autoimmune diseases and allograft rejection.

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SKU: 92111350726

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TLC
Port Orchard, US
★★★★★ 5
User friendly, Pet Hair Approved, Quite Powerful Robot Vacuum
Color: White
We prviously had an Eureka E10 vacuum and mop robot for 4 years. We had no idea what we were missing until we purchased this Narwal Freo X10 Pro. It maps very fast. It is extremely quite. The vacuum then mop with a refreshed mop head solution is much better than dragging around a robot mop pad with no way to clean it without removing and washing it. We have 3 Australian Sheppards that shed alot. This was the number one concern, whereas the prvious unit needed daily attention. Not a single hair tangle in the floating rotating brush of this unique Narwal Freo X10 Pro Robot vacuum. 4 months of no robot management is wonderful. The application was easy to use with a ton of customizable options. The AI option to recognize various floor types and throw rugs ensures a complete clean and quick simple setup. Lastly the price vs product was very reasonable. Great product! After spending many months researching, we are glad we made this investment.
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Reviewed in the United States on December 5, 2025
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Verified Purchase
A Happy Atheist
Battle Creek, US
★★★★★ 1
After five months, it's basically a brick
Color: White
We've had this robot for five months, and it isn't durable. It worked fine for a couple months. But now it works fine for maybe 20 minutes and then just starts spinning around or going back in forth in the same area wasting its battery. The endless troubleshooting does not help. Cleaning all the sensors, resetting the robot, remapping the house ... Nothing helps. It is only being used in about 1100 sq ft of total space, so it's just not that complicated. It's been trying (and failing) to vacuum our smallish living room for nearly five hours, after several resets/etc. Back when it did function, the vacuum is rather loud if you want it to actually pick up anything big enough to see. The vacuum and mop are both terrible at inner corners, and the intersection between rugs and hardwood flooring is a total miss. There's like a 12" strip along all rugs where mopping never occurs. Definitely not a machine to be used without supplemental sweeping and mopping. The machine insists on starting rugs at the corner, so it pulls up even pretty heavy rugs sometimes. It's sucks up items like socks instead of avoiding them. Also, the machine has never successfully left alone no-vacuum rugs or no-go areas, so some rooms (like with high pile rugs or Christmas tree stands) just don't work without physical barricades. Really, really makes me miss the old reliable roombas...
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Reviewed in the United States on April 21, 2026
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Verified Purchase
Alex Jones
Louisville, US
★★★★★ 5
This vacuum is a game changer
Color: White
Not all robotic vacuums are the same, and after testing so many of them in my life this one has outperformed the others hands down! From the suction power, to the battery life, and then the app I can't find a single thing I don't love. The robot is and to pickup small crumbs, dirt, the typical messes, but most importantly it picks up kitty litter like it's nothing. This is an instant game changer. I no longer need to clean up after a robot. It's amazing! The battery life is great! I have a 2500 sq ft house and it can handle all of it before charging. The "home base" makes this effortless where I just schedule my cleans and it takes care of the rest. The app is really nicely built. It's simple and easy to navigate but it also gives me all of the advanced options such as invisible walls and no-go zones. Overall, this is robotic vacuum is my new go-to and I look forward to using it for many years to come!
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Reviewed in the United States on April 14, 2026
K
Verified Purchase
Kallista Anne
Pawtucket, US
★★★★★ 4
$500, not $600. It isn’t worth $600
Color: White
You’re gonna need to put on some glasses and grab a drink for this one. Cons : - Has issues with “muddy mats” brand rugs and mats, along with light mats - It ate my socks - Will molest your standing fans and shoes and pet toys - Castor wheel is a hair magnet along with the “tangle less” floating brush - Mop heads get dirty after just one run of the entire house - It hates charging cables - And dryer sheets PROS: - Smarter than Shark brand vacuums - Excellent management of houses and avoiding most obstacles - It mops and vacuums well - Cleaning is very easy - Cat litter gets sucked up on the strong setting (not the super strong, though that works too) - Battery lasts for vacuuming most of the house - No navigation issues - Doesn’t mess up your furniture - IT WORKS IN THE DARK the floating brush though where the metal shaft sits inside the brush itself and the miniscule space between the spinning part and the brush itself gathers hair like a magnet and will give constant roller brush errors if not regularly cleaned. The castor wheel I swear has more hair than anything I’ve seen. Even the shark didn’t collect it this bad.
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Reviewed in the United States on April 17, 2026
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Verified Purchase
Rahul C
Lake Worth, US
★★★★★ 5
Value for Money- Exceptional performance and features!!!!
This vacuum/mop system is wonderful! I highly recommend it. This is bi-far the best vacuum and moping system which effectively cleans my floors and carpet. I've always been on the lookout for anything that can lighten my cleaning load. it’s been a real game-changer for my household routine. The self-washing and self-charging features are a huge win. I no longer have to worry about cleaning the mop or making sure it’s charged; it takes care of itself. It moves around furniture and other obstacles smoothly, rarely bumping into anything. It easily navigates tight spaces and corners, making sure every area gets cleaned. Value for Money: Considering all its features and how well it cleans, I think it’s a fantastic investment. It’s made keeping my home clean so much easier and less time-consuming. The robot vacuum was able to map my house successfully, the battery life is a bit longer than my previous robot vacuums, the suction is also great. I saw it go over crumbs in the kitchen and it picked up without any problems, and also has a mop functionality. It has a functioning app, very easy to use. The vacuum is also very quiet. By far, this is my favorite robot vacuum and I’ve tried many as I do not like to go around the house mopping and vacuuming. 10/10 would recommend this model - worth the investment. Overall I could not be happier with this purchase, my home is the cleanest it has been since I’ve first moved in.
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Reviewed in the United States on May 12, 2025

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