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Description
FITC Mouse Anti-Human CD6 Antibody (S-3174)Product Specification Host Mouse Antigen CD6 Synonyms T cell differentiation antigen CD6; T12; TP120 Location Cell membrane Accession P30203 Clone Number S 3174 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Mouse |
| Antigen | CD6 |
| Synonyms | T-cell differentiation antigen CD6; T12; TP120 |
| Location | Cell membrane |
| Accession | P30203 |
| Clone Number | S-3174 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD6 is a type I transmembrane glycoprotein primarily expressed on the surface of T cells and a subset of B cells, belonging to the scavenger receptor superfamily. Its structure comprises three scavenger receptor cysteine-rich (SRCR) domains, a proline-rich spacer region, and a cytoplasmic tail containing multiple conserved signaling motifs. By interacting with its ligand CD166 (ALCAM), which is expressed on antigen-presenting cells, CD6 directly participates in the regulation of T cell activation, proliferation, migration, and differentiation. As a co-stimulatory molecule in the T cell receptor signaling pathway, CD6 not only enhances T cell sensitivity to antigens but also influences immune tolerance by modulating thymocyte selection. In recent years, CD6 has emerged as a therapeutic target for autoimmune diseases such as multiple sclerosis, where monoclonal antibodies targeting the CD6-CD166 pathway can inhibit excessive immune responses, highlighting its critical role in immune regulation.
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