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Description
GABRA1 Recombinant Rabbit mAb (S-3254-10)Product Specification Host Rabbit Antigen GABRA1 Synonyms Gamma aminobutyric acid receptor subunit alpha 1; GABA(A) receptor subunit alpha 1 (GABAAR subunit alpha 1); Gabra 1; Gabra1 Immunogen Synthetic Peptide Location Cell membrane, Synapse Accession P62813 Clone Number S 3254 10 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample mouse brain, rat brain Predicted Reactivity CyMk, Bv, Or, Ck
Product Specification
| Host | Rabbit |
| Antigen | GABRA1 |
| Synonyms | Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1); Gabra-1; Gabra1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Synapse |
| Accession | P62813 |
| Clone Number | S-3254-10 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse brain, rat brain |
| Predicted Reactivity | CyMk, Bv, Or, Ck |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| IF | 1:500 | Ms, Rt |
Background
GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1) is the most abundant α-subunit of the pentameric GABA_A receptor, the brain’s principal fast inhibitory ion channel, and its TM2 helix lines the chloride-selective pore; mutations like A322D or E177A reduce surface expression or gating, causing severe epileptic encephalopathy, while single-nucleotide polymorphisms modulate sensitivity to benzodiazepines, ethanol and general anesthetics that bind at the α1/γ2 interface, making GABRA1 a pharmacological cornerstone for sedation, sleep and anesthesia as well as a high-priority target for precision therapy of genetic epilepsy.
Shipping Notes
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Exchange/Return Notes
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